Abstract
A variety of chronic diseases in infancy and childhood require long-term treatment with glucocorticoids including allergic diseases such as asthma, autoimmune diseases, or chronic inflammatory diseases of the gastrointestinal tract. While glucocorticoids are effective in controlling inflammatory processes, short- and long-term side effects are still a matter of concern for physicians as well as for the public. Side effects include the suppression of the hypothalamic-pituitary-adrenal (HPA) axis, skin atrophy, the incidence of cataracts and glaucoma, the reduction of bone mineral density as well as metabolic changes. A major concern in childhood is related to the possibility of reduced growth.
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References
Agertoft L, Pedersen S (1994) Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 88: 373–381
Agertoft L, Pedersen S (1998) Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide. Am J Respir Crit Care Med 157: 178–183
Agertoft L, Pedersen S (2000) Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med 343: 1064–1069
Hoffmann-Streb A, L’Allemand D, Niggemann B, Büttner P, Wahn U (1993) Nebennierenrindenfunktion bei Kindern mit Asthma bronchiale unter Therapie mit Fluticason. Monatsschr Kinderheilkd 141: 508–512
International Consensus Report on Diagnosis and Treatment of Asthma (1992) Eur Respir J 5: 601–641
Israel E, Banerjee TR, Fitzmaurice GM, Kotlov TV, LaHive K, LeBoff MS (2001) Effects of inhaled glucocorticoids on bone density in premenopausal women. N Engl J Med 345: 941–947
National Heart, Lung and Blood Institute (1997) National Asthma Education Program expert panel report. Guidelines for the diagnosis and management of asthma. Expert panel report No. 2 Bethesda, MD. NIH Publication No. 97–1051
National Institutes of Health (1995) National Heart, Lung and Blood Institute. Global Initiative for Asthma. NIH-Publication No. 95–3659
Pedersen S, Warner J, Wahn U, Staab D, Le Bourgeois M, van Essen-Zandvliet E, Arora S, Szefler SJ (2002) Growth systemic safety and efficacy during one year of asthma treatment with different beclomethasone dipropionate formulations: an open-label, randomized comparison of extrafine and conventional aerosols in children. Pediatrics (in press)
Scott MB, Skoner DP (1999) Short-term and long-term safety of budesonide inhalation suspension in infants and young children with persistent asthma. J Allergy Clin Immunol 104: 200–209
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Wahn, U. (2002). Special Problems in Glucocorticoid Treatment in Children. In: Cato, A.C.B., Schäcke, H., Asadullah, K. (eds) Recent Advances in Glucocorticoid Receptor Action. Ernst Schering Research Foundation Workshop, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04660-9_6
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DOI: https://doi.org/10.1007/978-3-662-04660-9_6
Publisher Name: Springer, Berlin, Heidelberg
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