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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 40))

Abstract

Few drugs have gained comparable importance, in almost any field of medical therapy, to corticosteroids. For the ophthalmologist, corticosteroids remain one of the basic therapeutics in a broad spectrum of inflammatory conditions. This review is intended to summarize some relevant aspects on the use of corticosteroids, their main indications, as well as their limitations in ophthalmology.

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References

  • Armaly MF (1966) The heritable nature of dexamethasone-induced ocular hypertension. Arch Ophthalmol 75: 32 - 35

    Article  PubMed  CAS  Google Scholar 

  • Barnes PJ, Adcock I (1993) Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 172: 436 - 441

    Article  Google Scholar 

  • Bettmann JW, Fund WE, Webster RG, Noyes PP, Vincent NJ (1967) Cataracto- genic effect of corticosteroids on animals. Am J Ophthalmol 63: 841 - 844

    Google Scholar 

  • Black RL, Oglesby RB, von Sallman L, et al (1960) Posterior subcapsular cataracts induced by corticoids in patients with rheumatoid arthritis. JAMA 174: 166 - 171

    Article  PubMed  CAS  Google Scholar 

  • Blake EM, Fasanella RM, Wong AS (1950) The effect of ACTH in glaucoma. Am J Ophthalmol 33: 1231 - 1235

    PubMed  CAS  Google Scholar 

  • Bodor B (1994) Designing softer ophthalmic drugs by soft drug approaches. J Ocul Pharmacol Ther 10: 3 - 15

    Article  CAS  Google Scholar 

  • Carnahan MC, Goldstein DA (2000) Ocular complications of topical, peri-ocu-lar and systemic corticosteroids. Curr Opin Ophthalmol 11: 478 - 483

    Article  PubMed  CAS  Google Scholar 

  • Chylack LT (1997) Cataracts and inhaled corticosteroids. N Engl J Med 337: 46 - 48

    Article  PubMed  Google Scholar 

  • Derby L, Maier WC (2000) Risk of cataract among users of intranasal corticosteroids. J Allergy Clin Immunol 105: 912 - 916

    Article  PubMed  CAS  Google Scholar 

  • Dick AD (1999) Immune regulation of uveoretinal inflammation. In: Pleyer U, Zierhut M, Behrens-Baumann W (eds) Immuno-ophthalmology. S. Karger AG, Basel, pp 187 - 203

    Chapter  Google Scholar 

  • Elkinton JR, Hunt AD Jr, Godfrey L, McCory WW, Stokes J Jr (1949) Effects of pituitary adrenocorticotropic hormone ( ACTH) therapy. JAMA 141: 1273-1279

    Google Scholar 

  • Foreman AR, Loreto JA, Tina LV (1977) Reversibility of corticosteroid-associated cataracts in children with the nephrotic syndrome. Am J Ophthalmol 84: 75 - 78

    Google Scholar 

  • Friedberg M, Pleyer U, Mondino BJ (1991) Device drug delivery: collagen shields, iontophoresis, pumps. Ophthalmology 98: 725 - 732

    PubMed  CAS  Google Scholar 

  • Garbe E, Suissa S, LeLorier J (1998) Association of inhaled corticosteroid use with cataract extraction in elderly patients. JAMA 280: 539 - 543

    Article  PubMed  CAS  Google Scholar 

  • Hanania NA, Chapman KR, Kesten S (1995) Adverse effects of inhaled corticosteroids. Am J Med 98: 196 - 208

    Article  PubMed  CAS  Google Scholar 

  • Howes JF (2000) Loteprednol etabonate: a review of ophthalmic clinical studies. Pharmazie 55: 178 - 183

    PubMed  CAS  Google Scholar 

  • Hull DS, Hine JE, Edelhauser HF, Hyndius RA (1974) Permeability of the isolated rabbit cornea to corticosteroids. Invest Ophthalmol Vis Sci 13: 457 - 459

    CAS  Google Scholar 

  • Jaffe GJ, Yang CH, Guo H, Denny JP, Lima C, Ashton P (2000) Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. Inv Ophthalmol Vis Sci 41: 3569 - 3575

    CAS  Google Scholar 

  • Johnson D, Gottanka J, Flugel C, Hoffmann F, Futa R, Lutjen Drecoll E (1997) Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids. Arch Ophthalmol 115: 375 - 383

    Article  PubMed  CAS  Google Scholar 

  • Kaplan HL (1984) Intermediate uveitis (pars planitis, chronic cyclitis): a four-step approach to treatment. In: Saari KM (ed) Uveitis update. Exerpta Medica 1984, Amsterdam, pp 169 - 172

    Google Scholar 

  • Leibowitz HM, Bartlett JD, Rich R, McQuirter H, Stewart R, Assil K (1996) Intraocular pressure-raising potential of 1% rimexolone in patients responding to corticosteroids. Arch Ophthalmol 114: 933 - 937

    Article  PubMed  CAS  Google Scholar 

  • Leibowitz HM, Kupferman A (1976) Kinetics of topically administered prednisolone acetate. Arch Ophthalmol 94: 1387 - 1389

    Article  PubMed  CAS  Google Scholar 

  • Mann WA, Markson DE (1950) A case of recurrent iritis and episcleritis on a rheumatic basis treated with ACTH. Am J Ophthalmol 33: 459 - 461

    Google Scholar 

  • McLean JM (1950) Clinical and experimental observation on the use of ACTH and cortisone in ocular inflammatory disease. Trans Am Ophthalmol Soc 48: 259

    Google Scholar 

  • Milani JK, Verbukh I, Pleyer U, Sumner H, Adamu SA, Halabi Hi, Chou HI, Lee DA, Mondino BJ (1993) Collagen shields impregnated with gentamycin-dexamethasone combination as a potential drug delivery device. Am J Ophthalmol 116: 622 - 627

    PubMed  CAS  Google Scholar 

  • Mitchell P, Cumming RG, Mackey DA (1999) Inhaled corticosteroids, family history, and risk of glaucoma. Ophthalmology 106: 2301 - 2306

    Article  PubMed  CAS  Google Scholar 

  • Novack GD, Howes J, Crockett RS, Sherwood MB (1998) Change in intraocular pressure during long-term use of loteprednol etabonate. J Glaucoma 7: 266 - 269

    PubMed  CAS  Google Scholar 

  • Olson JA, Steffensen EH, Margulis RR, Smith RW, Whitney EL (1950) Effect of ACTH on certain inflammatory diseases of the eye. JAMA 142: 1276 - 1278

    Article  Google Scholar 

  • Ozerdem U, Levi L, Cheng L, Song MK, Scher C, Freeman WR (2000) Systemic toxicity of topical and periocular corticosteroid therapy in an 11-yearold male with posterior uveitis. Am J Ophthalmol 130: 240 - 241

    Article  PubMed  CAS  Google Scholar 

  • Pleyer U, Lutz S, Jusko WJ, Nguyen K, Narawane M, Rückert D, Mondino BJ, Lee VHL (1993) Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. Invest Ophthalmol Vis Sci 34: 2737 - 2742

    PubMed  CAS  Google Scholar 

  • Pleyer U, Elkins B, Rückert D, Lutz S, Grammer J, Chou J, Schmidt KH, Mondino BJ (1994) Ocular absorption of cyclosporine A from liposomes incorporated into collagen shields. Curr Eye Res 13: 177 - 181

    Article  PubMed  CAS  Google Scholar 

  • Pleyer U, Rieck P, Ritter T, Hartmann C (1998) Immunreaktion nach perforierender Keratoplastik. Ophthalmologe 95: 444 - 459

    Article  PubMed  CAS  Google Scholar 

  • Pleyer U, Liekfeld A, Baatz H, Hartmann C (1999) Pharmakologische Modulation immunmediierter Erkrankungen des Auges. Klin Monatsbl Augenheilkd 214: 160 - 170

    Article  PubMed  CAS  Google Scholar 

  • Polansky JR, Fauss DJ, Zimmerman CC (2000) Regulation of TIGR/MYOC gene expression in human trabecular meshwork cells. Eye 14: 503 - 514

    Article  PubMed  Google Scholar 

  • Rauz S, Walker EA, Shackleton CH, Hewison M, Murray PI, Stewart PM (2001) Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye. Invest Ophthalmol Vis Sci 42: 2037 - 2042

    PubMed  CAS  Google Scholar 

  • Southern AL, Altman K, Vittek J, Boniuk V, Gordon GG (1976) Steroid metabolism in ocular tissues of the rabbit. Invest Ophthalmol Vis Sci 15: 222 - 228

    Google Scholar 

  • Southern AL, Gordon GG, Yeh HS, Dunn MW, Weinstein BI (1977) Receptors for glucocorticoids in the lens epithelium of the calf. Science 200: 1177 - 1178

    Article  Google Scholar 

  • Stern JJ (1953) Acute glaucoma during cortisone therapy. Am J Ophthalmol 36: 389 - 390

    PubMed  CAS  Google Scholar 

  • Stone EM, Tingert JH, Wallace LM, Nguyen TD, Polansky JR, Sheffield VC (1997) Identification of a gene that causes primary open-angle glaucoma. Science 275: 668 - 670

    Article  PubMed  CAS  Google Scholar 

  • Sugar J, Burde RM, Sugar A, Waltman SR, Kripalani KJ, Weliky I, Becker B (1972) Tetrahydrotriamcinolone and triamcinolone I. Ocular penetration. Invest Ophthalmol Vis Sci 11: 890-893

    Google Scholar 

  • Tamada Y, Miyashita H, Ono S (1980) Studies on phospholipid metabolism of rabbit lens with special references to long-term topical administration of steroid. Jap J Ophthalmol 24: 289 - 296

    CAS  Google Scholar 

  • Urban RC Jr, Cotlier E (1986) Corticosteroid-induced cataracts. Sury Ophthalmol 31: 102 - 110

    Article  CAS  Google Scholar 

  • Watson D, Noble MJ, Dutton GN, Midgley JM, Healey TM (1988) Penetration of topically applied dexamethasone alcohol into human aqueous humor. Arch Ophthalmol 106: 686 - 687

    Article  PubMed  CAS  Google Scholar 

  • Weiner A, BenEzra D (1991) Clinical patterns and associated conditions in chronic uveitis. Am J Ophthalmol 112: 151 - 158

    PubMed  CAS  Google Scholar 

  • Woods AC (1950) Clinical and experimental observations on the use of ACTH and cortisone in ocular inflammatory disease. Am J Ophthalmol 33: 1325 - 1349

    PubMed  CAS  Google Scholar 

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© 2002 Springer-Verlag Berlin Heidelberg

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Pleyer, U., Sherif, Z. (2002). Corticosteroids in Ophthalmology. In: Cato, A.C.B., Schäcke, H., Asadullah, K. (eds) Recent Advances in Glucocorticoid Receptor Action. Ernst Schering Research Foundation Workshop, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04660-9_5

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  • DOI: https://doi.org/10.1007/978-3-662-04660-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-04662-3

  • Online ISBN: 978-3-662-04660-9

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