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Thyroid Cancer: Treatment with Thyroid Hormone

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Thyroid Cancer

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Abstract

All patients with thyroid cancer must be treated with thyroid hormone after thyroidectomy for correction of surgically induced hypothyroidism and to suppress stimulated growth of persistent or recurrent thyroid cancer by reducing thyroidstimulating hormone (TSH) levels.

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References

  1. Balme HW (1954) Metastatic carcinoma of the thyroid successfully treated with thyroxine. Lancet 1: 812–813

    Article  Google Scholar 

  2. Bartalena L, Martino E, Pacciarotti A, Grasso L, Aghini-Lombardi F, Buratti L, Bambini G, Breccia M, Pinchera A (1987) Factors affecting suppression of endogenous thyrotropin secretion by thyroxine treatment: retrospective analysis in athyreotic and goitrous patients. J Clin Endocrinol Metab 64: 849–855

    Article  PubMed  CAS  Google Scholar 

  3. Baudin E, Schlumberger M (1994) Levothyroxine treatment in patients with differentiated thyroid carcinoma. In: Orgiazzi J, Ledere J (eds) The thyroid and tissues. Schattauer, Stuttgart, pp 213–215

    Google Scholar 

  4. Biondi B, Fazio S, Carella C, Amato G, Cittadini A, Lupoli G, Sacca L, Bessastella A, Lombardi G (1993) Cardiac effects of long-term thyrotropin-suppressive therapy with levothyroxine. J Clin Endocrinol Metab 77: 334–338

    Article  PubMed  CAS  Google Scholar 

  5. Biondi B, Fazio S, Carella C, Sabatini D, Amato G, Cittadini A, Bellastella A, Lombardi G, Sacca L (1994) Control of adrenergic overactivity by b-blockade improves the quality of life in patients receiving long-term suppressive therapy with levothyroxine. J Clin Endocrinol Metab 78:1028–1033

    Google Scholar 

  6. Burmeister LA, Goumaz MO, Mariash CN, Oppenheimer JH (1992) Levothyroxine dose requirements for thyrotropin suppression in the treatment of differentiated thyroid cancer. J Clin Endocrinol Metab 75: 344–350

    Article  PubMed  CAS  Google Scholar 

  7. Busnardo B, Bui F, Girelli ME (1983) Different rates of serum thyrotropin suppression after total body scan in patients with thyroid cancer: effect of regular doses of thyroxine and triiodothyronine. J Endocrinol Invest 6: 35–40

    PubMed  CAS  Google Scholar 

  8. Carayon P, Thomas-Morvan C, Castanas E, Tubiana M (1980) Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity. J Clin Endocrinol Metab 51: 915–920

    Article  PubMed  CAS  Google Scholar 

  9. Cooper DS, Specker B, Ho M, Sperling M, Ladenson PW, Ross DS, Ain KB, Bigos T, Brierley JD, Haugen BR, Klein I, Robbins J, Sherman SL, Taylor T, Maxon HR (1998) Thyrotropin suppression and disease progression in patients with differentiated thyroid cancer: results from National Thyroid Cancer Treatment Cooperative Registry. Thyroid 8: 737–744

    Article  PubMed  CAS  Google Scholar 

  10. Doniach I (1963) Effects including carcinogenesis of I-131 and x-rays on the thyroid of experimental animals: a review. Health Phys 9: 1357–1362

    Article  PubMed  CAS  Google Scholar 

  11. Dunhill TP (1937) Surgery of the thyroid gland (The Lettsomian Lectures). Br Med J 1: 460–461

    Article  Google Scholar 

  12. Franklyn JA, Betteridge J, Daxkin J, Holder R, Oates GD, Parle JV, Lilley J Heath DA, Sheppard MC (1992) Long term thyroxine treatment and bone mineral density. Lancet 340: 9–13

    Article  PubMed  CAS  Google Scholar 

  13. Gam AN, Jensen GF, Hasselstrom K, Olsen M, Sierbaek Nielsen K (1991) Effect of thyroxine therapy on bone metabolism in substituted hypothyroid patients with normal or suppressed levels of TSH. J Endocrinol Invest 14: 451–455

    PubMed  CAS  Google Scholar 

  14. Hays MT (1989) Intestinal absorption and secretion of the thyroid hormones. Thyroid Today 12: 1–9

    Google Scholar 

  15. Jennings PE, O’Malley BP, Griffin KE, Northover B, Rosenthal FD (1984) Relevance of increased serum thyroxine concentrations associated with normal serum triiodothyronine values in hypothyroid patients receiving thyroxine: a case for “tissue” thyrotoxicosis. Br Med J 289: 1645–1647

    Article  CAS  Google Scholar 

  16. Kahn BB, Weintraub BD, Csako G, Zweig MH (1988) Factitious elevation of thyrotropin in a new ultrasensitive assay: implications for the use of monoclonal antibodies in “sandwich” immunoassay. J Clin Endocrinol Metab 66: 526–533

    Article  PubMed  CAS  Google Scholar 

  17. Ladenson PW (1993) Editorial: thyrotoxicosis and the heart: something old and something new. J. Clin Endocrinol Metab 77: 332–333

    Article  PubMed  CAS  Google Scholar 

  18. Leese GP, Jung RT, Guthrie C, Waugh N, Browning MCK (1992) Morbidity in patients on L-thyroxine: a comparison of those with a normal TSH to those with a suppressed TSH. Clin Endocrinol 37: 500–503

    Article  CAS  Google Scholar 

  19. Lindsay S, Chaikoff IL (1964) The effects of irradiation on the thyroid gland with particular reference to the induction of thyroid neoplasms: a review. Cancer Res 24: 1099–1107

    PubMed  CAS  Google Scholar 

  20. Mandel SJ, Larsen PR, Seely EW, Brent GA (1990) Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med 323: 91–96

    Article  PubMed  CAS  Google Scholar 

  21. Marcocci C, Golia F, Bruno-Bossio G, Vignali E, Pinchera A (1994) A carefully monitored levothyroxine suppressive therapy is not associated with bone loss in premenopausal women. J Clin Endocrinol Metab 78: 818–823

    Article  PubMed  CAS  Google Scholar 

  22. Mazzaferri EL, Jhiang SM (1994) Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97: 418–428

    Article  PubMed  CAS  Google Scholar 

  23. Mechelany C, Schlumberger M, Challeton C, Comoy E, Parmentier C (1991) TRIAC (3,5,34triiodothyroacetic acid) has parallel effects at the pituitary and peripheral tissue levels in thyroid cancer patients treated with L-thyroxine. Clin Endocrinol 35: 123–128

    Article  CAS  Google Scholar 

  24. Nadler NJ, Mandavia M, Goldberg M (1970) The effect of hypophysectomy on the experimental production of rat thyroid neoplasms. Cancer Res 30: 1909–1911

    PubMed  CAS  Google Scholar 

  25. Petersen K, Bengtsson C, Lapidus L, Lindstedt G, Nystrom E (1990) Morbidity, mortality and quality of life for patients treated with levothyroxine. Arch Intern Med 150: 2077–2081

    Article  PubMed  CAS  Google Scholar 

  26. Pujol P, Daures JP, Nsakala N, Baldes L, Bringer J, Jaffiol C (1998) Degree of thyrotropin suppression as a prognostic determinant in differentiated thyroid cancer. J Clin Endocrinol Metab 81: 4318–4323

    Article  Google Scholar 

  27. Ross DS (1991) Monitoring L-thyroxine therapy: lessons from the effects of L-thyroxine on bone density. Am J Med 91: 1–4

    Article  PubMed  CAS  Google Scholar 

  28. Sawin CT, Herman, T, Molitch ME, London MH, Kramer SM (1983) Aging and the thyroid. Decreased requirement of thyroid hormone in older hypothyroid patients. Am J Med 75: 206–209

    Article  PubMed  CAS  Google Scholar 

  29. Sawin CT, Geller A, Wolf PA, Belanger AJ, Baker E, Bacharach P, Wilson PWF, Benjamin EJ, D’Agostino RB (1994) Low serum thyrotropin concentrations as a risk factor for a trial fibrillation in older persons. N Engl J Med 331: 1249–1252

    Article  PubMed  CAS  Google Scholar 

  30. Schlumberger M, Charbord P, Fragu P, Lumbroso J, Parmentier C, Tubiana M (1980) Circulating thyroglobulin and thyroid hormones in patients with metastases of differentiated thyroid carcinoma: relationship to serum thyrotropin levels. J Clin Endocrinol Metab 51: 513–519

    Article  PubMed  CAS  Google Scholar 

  31. Schlumberger M, Charbord P, Fragu P, Gardet P, Lumbroso J, Parmentier C, Tubiana M (1983) Relationship between TSH stimulation and radioiodine uptake in lung metastases of differentiated thyroid carcinoma. J Clin Endocrinol Metab 57: 148–151

    Article  PubMed  CAS  Google Scholar 

  32. Schlumberger M, De Vathaire F, Ceccarelli C, Delisle MJ, Francese C, Couette JE, Pinchera A, Parmentier C (1996) Exposure to radioiodine (I-131) for scintigraphy or therapy does not preclude pregnancy in thyroid cancer patients. J Nucl Med 37: 606–612

    PubMed  CAS  Google Scholar 

  33. Schneider AB, Line BR, Goldman JM, Robbins J (1981) Sequential serum thyroglobulin determinations, 131-I scans and 131-I uptakes after tri-iodothyronine withdrawal in patients with thyroid cancer. J Clin Endocrinol Metab 53: 1199–1206

    Article  PubMed  CAS  Google Scholar 

  34. Solomon BL, Wartofsky L, Burman KD (1993) Prevalence of fractures in postmenopausal women with thyroid disease. Thyroid 3: 17–23

    Article  PubMed  CAS  Google Scholar 

  35. Uzzan B, Campos J, Cucherat M, Nony B, Boissel JP, Perret JY (1996) Effects on bone mass of long-term treatment with thyroid hormone: a meta-analysis. J Clin Endocrinol Metab 81: 4278–4279

    Article  PubMed  CAS  Google Scholar 

  36. Wartofsky L (2000) Thyroid cancer. A comprehensive guide to clinical management. Humana Press, Totowa, New Jersey

    Google Scholar 

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Authors
  1. P.-M. Schumm-Draeger
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Editors and Affiliations

  1. Klinik und Poliklinik für Nuklearmedizin, Rheinische Friedrich-Wilhelms-Universität, Sigmund-Freud-Straße 15, 53127, Bonn, Germany

    H.-J. Biersack (Professor Dr. med.) (Professor Dr. med.)

  2. Abteilung für Nuklearmedizin, Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany

    F. Grünwald (Professor Dr. med.) (Professor Dr. med.)

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© 2001 Springer-Verlag Berlin Heidelberg

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Schumm-Draeger, PM. (2001). Thyroid Cancer: Treatment with Thyroid Hormone. In: Biersack, HJ., Grünwald, F. (eds) Thyroid Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04610-4_8

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  • DOI: https://doi.org/10.1007/978-3-662-04610-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-04612-8

  • Online ISBN: 978-3-662-04610-4

  • eBook Packages: Springer Book Archive

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