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Thyroid Cancer pp 285-294 | Cite as

Follow-up of Medullary Thyroid Cancer

  • T. Schilling
  • R. Ziegler

Abstract

A precondition for effective follow-up is knowledge of whether the patient is suffering from the sporadic or the familial form of medullary thyroid cancer (MTC). Mutational analysis of RET proto-oncogene helps to distinguish between these two forms of MTC. In 11.6% of patients with apparent sporadic MTC, a mutation in the RET proto-oncogene is found. This means that these patients have the familial form of MTC, i.e., they suffer from multiple endocrine neoplasia (MEN) type 2 (Table 18.1) [2]. As the clinical presentation may be identical in both forms, every patient with MTC should undergo a mutational analysis of the RET proto-oncogene to distinguish between the sporadic and the familial form (Table 18.2). Patients suffering from MEN 2 have a 50%–100% chance of developing pheochromocytoma and a 10%–20% chance of developing hyperparathyroidism (Table 18.1).

Keywords

Thyroid Cancer Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Type Medullary Thyroid Multiple Endocrine Neoplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • T. Schilling
  • R. Ziegler

There are no affiliations available

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