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Thyroid Cancer pp 225-235 | Cite as

Thyroid Cancer in Chernobyl Children

  • C. Reiners
  • J. Biko
  • E. P. Demidchik
  • V. Drozd

Abstract

It has been well known for 50 years that exposure of the thyroid to ionizing radiation in childhood produces an appreciable cancer risk [7]. The thyroid gland and the bone marrow are considered to be the most radiosensitive cancer sites [24]. Concerning thyroid cancer, many epidemiological studies in populations of children treated with external radiotherapy for benign or malignant lesions in the head and neck region have been published [14, 24, 25, 29, 30]. The diverse indications for treatment have included skin hemangioma, enlarged thymus and tonsils, lymphoid hyperplasia, tuberculous adenitis, acne, and tinea capitis. A pooled analysis [24] using the data of cohort studies in individuals exposed to acute external ionizing radiation before the age of 20 years found an average excess relative risk of 7.7 per Gy [95% confidence interval (CI) 4.9–12], while the excess absolute risk was 4.4 per 104 person-year Gy (95% CI 1.9–10). A linear dose-response function was found to fit the data well; the risk was about 30% lower for fractionated doses than for unfractionated exposure. Almost no thyroid cancers prior to 5 years after irradiation have been reported; the pooled analysis suggested that the excess relative risk per Gy was greatest about 15 years after exposure, but was still elevated 40 or more years after irradiation [24].

Keywords

Thyroid Cancer Thyroid Carcinoma Papillary Thyroid Cancer Thyroid Tumor Differentiate Thyroid Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • C. Reiners
  • J. Biko
  • E. P. Demidchik
  • V. Drozd

There are no affiliations available

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