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Miniantibodies

  • Chapter
Book cover Antibody Engineering

Part of the book series: Springer Lab Manuals ((SLM))

Abstract

The term “miniantibodies” describes artificial multivalent or multispecific recombinant antibody fragments. They resemble natural antibodies in carrying two or four binding sites with a flexible arrangement and a long “wing span” but they are much smaller, as they consist only of fusions of a scFv to an oligomerization module. Applications of multivalent and bispecific antibody fragments in a variety of formats have been reviewed (Plückthun and Pack 1997; Carter and Merchant 1997). Approaches to quantify the avidity gain achieved by the multivalency effect present in all the described miniantibody models have been reported (Crothers and Metzger 1972, Plückthun and Pack 1997, Müller et al. 1998b).

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Authors and Affiliations

  1. Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland

    Peter Lindner & Andreas Plückthun

Authors
  1. Peter Lindner
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  2. Andreas Plückthun
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Correspondence to Andreas Plückthun .

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Editors and Affiliations

  1. Institut für Molekularbiologie und Tumorforschung, Universität Marburg, Emil-Mannkopff-Str. 2, 35033, Marburg, Germany

    Roland Kontermann

  2. Molekulare Genetik, Universität Heidelberg, Im Neuenheimer Feld 230, 69120, Heidelberg, Germany

    Stefan Dübel

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© 2001 Springer-Verlag Berlin Heidelberg

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Lindner, P., Plückthun, A. (2001). Miniantibodies. In: Kontermann, R., Dübel, S. (eds) Antibody Engineering. Springer Lab Manuals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04605-0_43

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  • DOI: https://doi.org/10.1007/978-3-662-04605-0_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41354-7

  • Online ISBN: 978-3-662-04605-0

  • eBook Packages: Springer Book Archive

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