Humanising Antibodies by CDR Grafting
• Short serum half life.
• Poor utilisation of human effector functions via the mouse constant regions.
• Rapid onset of a human anti-globulin response to mouse specific residues — also known as the HAMA (Human Anti-Mouse Antibody) response.
KeywordsPolymerase Chain Reaction Reaction Chimeric Antibody Potential Glycosylation Site Polymerase Chain Reaction Reaction Mixture Variable Region Gene
Unable to display preview. Download preview PDF.
- Kabat E A, Wu TT, Perry HM, Gottesman KS, Foeller C (1991) Sequences of proteins of immunological interest, Fifth Edition, U.S. Department of Health and Human Services, U.S. Government Printing OfficeGoogle Scholar
- Maeda H, Matsushita S, Eda Y, Kimachi K, Tokiyoshi S, Bendig MM (1991) Hum Antibod Hvbridomas 2: 124Google Scholar