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Andrology pp 367-375 | Cite as

Cryopreservation of Human Semen

  • S. Kliesch
  • A. Kamischke
  • E. Nieschlag

Abstract

Malignant diseases in children and adults can be cured by surgery, chemo- or radiotherapy in a high percentage of cases, resulting in increased survival rates. In those patients where this is not possible, an increase of disease-free intervals may be achieved by adequate therapeutic strategies. Therefore the implications for long-term toxicity and delayed results of therapeutic intervention become more and more important. Chemo- or radiotherapy as well as surgical intervention have a tremendous influence on male reproductive functions. Their negative influence on reproduction depends on the therapeutic modalities, the substances and dosages chosen and can be irreversible.

Keywords

Sperm Motility Sperm Concentration Human Sperm Testicular Tumor Epididymal Sperm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alvarez JG, Storey BT (1993) Evidence that membrane stress contributes more than lipid peroxidation to sublethal cryodamage in cryopreserved human sperm: glycerol and other polyols as sole cryoprotectant. J Androl 14:199–208PubMedGoogle Scholar
  2. Bahadur G, Ralph D (1999) Gonadal tissue cryopreservation in boys with paediatric cancers. Hum Reprod 14:11–17PubMedCrossRefGoogle Scholar
  3. Belker AM, Bergamini DA (1997) The feasibility of cryopreservation of sperm harvested intraoperatively during vasectomy reversals. J Urol 157:1292–1294PubMedCrossRefGoogle Scholar
  4. Brämswig JH, Heimes E, Heiermann W, Schlegel W, Nieschlag E (1990) The effects of different cumulative doses of chemotherapy on testicular function. Results in 75 patients treated for Hodgkin’s disease during childhood or adolescence. Cancer 65:1298–1302PubMedCrossRefGoogle Scholar
  5. Byrd W, Bradshaw K, Carr B, Edman C, Odom J, Ackerman G (1990) A prospective randomized study of pregnancy rates following intrauterine and intracervical insemination using frozen donor sperm. Fertil Steril 53:521–527PubMedGoogle Scholar
  6. Chan SYW, Pearlstone A, Uhler M, Tucker M, Greenspoon R, Leung A, Wang C (1993) Human spermatozoal tail hypo-osmotic swelling test, motility characteristics in hypotonic saline, and survival of spermatozoa after cryopreservation. Hum Reprod 8:717–721PubMedGoogle Scholar
  7. Chung PH, Yeko TR, Mayer JC, Sanfor EJ, Maroulis GB (1995) Assisted fertility using electroejaculation in men with spinal cord injury — a review of literature. Fertil Steril 64:1–9PubMedGoogle Scholar
  8. Cooper TG, Neuwinger J, Bahrs S, Nieschlag E (1992) Internal quality control of semen analysis. Fertil Steril 58:172–177PubMedGoogle Scholar
  9. Craft I, Tsirigotis M (1995) Debates: simplified recovery, preparation and cryopreservation of testicular spermatozoa. Hum Reprod 10:1623–1627PubMedGoogle Scholar
  10. Critser JK (1995) Therapeutic insemination by donor I: a review of its efficacy. Reprod Med Rev 4:9–17CrossRefGoogle Scholar
  11. De Geyter C, De Geyter M, Schneider HPG, Nieschlag E (1992) Subnormal sperm parameters in conventional semen analysis are associated with discrepancies between fertilization and pregnancy rates in in vitro fertilization and embryo transfer. Int J Androl 15:485–491PubMedCrossRefGoogle Scholar
  12. Devroey P, Liu J, Nagy Z, Goossens A, Tounaye H, Camus M, Van Steirteghem A, Silber S (1995) Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia. Hum Reprod 10:1457–1460PubMedCrossRefGoogle Scholar
  13. Dodds L, Marrett LD, Tomkins DJ, Green B, Sherman G (1993) Case-control study of congenital anomalies in children of cancer patients. Br Med J 307:164–168CrossRefGoogle Scholar
  14. Friedler S, Raziel A, Soffer Y, Strassburger D, Komarovsky D, Ron-El R (1997) Intracytoplasmic injection of fresh and cryopreserved testicular spermatozoa in patients with nonobstructive azoospermia —rative study. Fertil Steril 68:892–897PubMedCrossRefGoogle Scholar
  15. Genescà A, Bene J, Caballín MR, Miró R, Germà JR, Egozcue J (1990) Significance of structural chromosome aberrations in human sperm: analysis of induced aberrations. Hum Genet 85:495–499PubMedCrossRefGoogle Scholar
  16. Hammerstedt RH, Graham JK, Nolan JP (1990) Cryopreservation of mammalian sperm: what we ask them to survive. J Androl 11:73–88PubMedGoogle Scholar
  17. Hansen PV, Glavind K, Panduro J, Pedersen M (1991) Paternity in patients with testicular germ cell cancer: pretreatment and post-treatment findings. Eur J Cancer 27:1385–1389PubMedCrossRefGoogle Scholar
  18. Hoagland H, Pincus G (1942) Revival of mammalian sperm after immersion in liquid nitrogen. J Gen Physiol 25:337–339PubMedCrossRefGoogle Scholar
  19. Holland-Moritz H, Krause W (1990) Inanspruchnahme von Sperma-Kryodepots bei Tumorpatienten. Hautarzt 41:204–206PubMedGoogle Scholar
  20. Jahnel F (1938) Über die Widerstandsfähigkeit von menschlichen Spermatozoen gegenüber starker Kälte. Klin Wochenschr 17:1273–1274CrossRefGoogle Scholar
  21. Jezek D, Knuth UA, Schulze W (1998) Successful testicular sperm extraction (TESE) in spite of high serum follicle stimulating hormone and azoospermia: correlation between testicular morphology, TESE results, semen analysis and serum hormone values in 103 infertile men. Hum Reprod 13:1230–1234PubMedCrossRefGoogle Scholar
  22. Keck C, Nieschlag E (1993) Kryokonservierung von Spermien als Zeugungsreserve für onkologische Patienten. Internist 34775–780Google Scholar
  23. Kliesch S, Behre HM, Jürgens H, Nieschlag E (1996) Cryopreservation of semen from adolescent patients with malignancies. Med Ped Oncol 26:20–27CrossRefGoogle Scholar
  24. Köhn FM, Schill WB (1988) Kryospermabank München — Zwischenbilanz 1974–1986. Hautarzt 39:91–96PubMedGoogle Scholar
  25. Kreuser ED, Klingmüller D, Thiel E (1992) Diagnostik und Prognose gonadaler Toxizität nach Chemotherapie und Bestrahlung. Dtsch Med Wochenschr 117:1810–1817PubMedCrossRefGoogle Scholar
  26. Lass A, Akagbosu F, Abusheikha N, Hassouneh M, Blayney M, Avery S, Brinsden P (1998) A programme of semen cryopreservation for patients with malignant disease in a tertiary infertility centre: lessons from 8 years’ experience. Hum Reprod 13:3256–3261PubMedCrossRefGoogle Scholar
  27. Morris GJ, Acton E, Avery S (1999) A novel approach to sperm cryopreservation. Hum Reprod 14:10132–1021Google Scholar
  28. Naysmith TE, Blake DA, Harvey VJ, Johnson NP (1998) Do men undergoing sterilizing cancer treatment have a fertile future? Hum Reprod 13:3250–3255PubMedCrossRefGoogle Scholar
  29. Neuwinger J, Behre HM, Nieschlag E (1990) External quality control in the andrology laboratory: an experimental multicenter trial. Fertil Steril 54:308–314PubMedGoogle Scholar
  30. Palermo G, Joris H, Devroey P, Van Steirteghem AC (1992) Pregnancies after intracytoplasmatic injection of single spermatozoon into an oocyte. Lancet 340:17–18PubMedCrossRefGoogle Scholar
  31. Palermo GD, Schlegel PN, Hariprashad JJ, Ergün B, Mielnik A, Zaninovic N, Veeck LL, Rosenwaks Z (1999) Fertilization and pregnancy outcome with intracytoplasmic sperm injection for azoospermic men. Hum Reprod 14:741–748PubMedCrossRefGoogle Scholar
  32. Péréz-Sanchez F, Cooper TG, Yeung CH, Nieschlag E (1994) Improvement in quality of cryopreserved human spermatozoa by swim-up before freezing. Int J Androl 17:115–119PubMedCrossRefGoogle Scholar
  33. Polge C, Smith AU, Parkes AS (1942) Revival of spermatozoa after vitrification and dehydration at low temperatures. Nature 164–167Google Scholar
  34. Rousseaux S, Sèle B, Cozzi J, Chevret E (1993) Immediate rearrangement of human sperm chromosomes following in-vivo irradiation. Hum Reprod 8:903–907PubMedGoogle Scholar
  35. Rufat P, Olivennes F, de Mouzon J, Dhean M, Frydman R (1994) Task force report on the outcome of pregnancies and children conceived by in vitro fertilization (France: 1987 to 1989). Fertil Steril 61:324–330PubMedGoogle Scholar
  36. Salzbrunn A, Benson DM, Holstein AF, Schulze W (1996) A new concept for the extraction of testicular spermatozoa as a tool for assisted fertilization (ICSI). Hum Reprod 11:752–755PubMedCrossRefGoogle Scholar
  37. Sanger WG, Olson JH, Sherman JK (1992) Semen cryobanking for men with cancer — criteria change. Fertil Steril 58:1024–1027PubMedGoogle Scholar
  38. Schenker JG, Ezra Y (1994) Complications of assisted reproductive techniques. Fertil Steril 61:411–422PubMedGoogle Scholar
  39. Schlatt S, Rosiepen G, Weinbauer GF, Rolf C, Brook PF, Nieschlag E (1999) Germ cell transfer into rat, bovine, monkey and human testes. Hum Reprod 14:144–150PubMedCrossRefGoogle Scholar
  40. Sherman JK (1963) Improved methods of preservation of human spermatozoa by freezing and freeze drying. Fertil Steril 14:723–729Google Scholar
  41. Shettles LB (1940) The respiration of human spermatozoa and their response to various cases and low temperature. Am J Physiol 128:408–415Google Scholar
  42. Silber SJ, Van Steirteghem AC, Liu J, Nagy Z, Tournaye H, Devroey P (1995) High fertilization and pregnancy rate after intracytoplasmic sperm injection with spermatozoa obtained from testicle biopsy. Hum Reprod 10:148–152PubMedCrossRefGoogle Scholar
  43. Smith KD, Steinberger E (1973) Survival of spermatozoa in a human sperm bank. J Am Med Assoc 223:774–774CrossRefGoogle Scholar
  44. Viviani S, Ragni G, Santoro A, Perotti L, Caccamo E, Negretti E, Valagussa P, Bonadonna G (1991) Testicular dysfunction in Hodgkin’s disease before and after treatment. Eur J Cancer 27:1389–1392PubMedCrossRefGoogle Scholar
  45. Wang R, Sikka SC, Veeraragavan K, Bell M, Hellstrom WJG (1993) Platelet activating factor and pentoxifylline as human sperm cryoprotectants. Fertil Steril 60:711–715PubMedGoogle Scholar
  46. Watson PF, Critser JK, Mazur P (1992) Sperm preservation: fundamental cryobiology and practical implications. In: Templeton AA, Drife JO (eds) Infertility. Springer, Berlin Heidelberg New York, pp 101–114CrossRefGoogle Scholar
  47. WHO Laborhandbuch zur Untersuchung des menschlichen Ejakulates und der Spermien-Zervikalschleim-Interaktion (1999). Übersetzt von: Nieschlag E, Nieschlag S, Bals-Pratsch M, Behre HM,Knuth UA, Meschede D, Niemeier M, Schick A, 4th edn. Springer, Berlin Heidelberg New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • S. Kliesch
  • A. Kamischke
  • E. Nieschlag

There are no affiliations available

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