Abstract
With the Human Genome Project reaching its goal to determine the complete sequence of the human genome, questions concerning the use of this information for the improvement of health and in particular for the prevention of human disease are shifting more and more to the centre of attention. Obviously, an increasing number of DNA sequences with so far unknown function will be linked to disease phenotypes and will give rise to novel diagnostic and therapeutic strategies. The genetic background of many monogenetic diseases will finally be discovered, and for many other conditions, genetic factors involved in particular diseases, often manifesting only later in life, will be revealed. Therapeutic approaches will in many cases be based on the development of novel drugs, but progress made in the field of gene delivery and expression will also lead to effective gene therapy strategies using the DNA itself as the therapeutic agent. It can be predicted that the continuously broadening array of genome-based diagnostic and predictive tests will lead to increasing demands for preventive measures to avoid diseases rather than having to treat such conditions.
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Coutelle, C. et al. (2001). Fetal Somatic Gene Therapy — A Preventive Approach to the Treatment of Genetic Disease: The Case For. In: Holzgreve, W., Lessl, M. (eds) Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy. Ernst Schering Research Foundation Workshop, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04469-8_7
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DOI: https://doi.org/10.1007/978-3-662-04469-8_7
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