Abstract
Lentiviral vectors, owing to their ability to deliver transgenes in tissues that long appeared irremediably refractory to stable genetic manipulation, open exciting perspectives for the genetic treatment of a wide array of hereditary as well as acquired disorders, in particular of the lymphohematopoietic system.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Blömer U et al (1997) Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol 71: 6641–6649
Bukrinsky M et al (1992) Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc Natl Acad Sci USA 89: 6580–6584
Bukrinsky MI et al (1993) A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature 365: 666–669
Case SS et al (1999) Stable transduction of quiescent CD34+ CD38− human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci USA 96: 2988–2993
Douglas J, Kelly P, Evans JT, Garcia JV (1999) Efficient transduction of human lymphocytes and CD34+ cells via human immunodeficiency virus-based gene transfer vectors. Hum Gene Ther 10: 935–945
Dull T et al (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72: 8463–8471
Gallay P, Chin D, Hope TJ, Trono D (1997) HIV-1 infection of nondividing cells mediated through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci USA 94: 9825–9830
Gallay P, Stitt V, Mundy C, Oettinger M, Trono, D (1996) Role of the karyopherin pathway in human immunodeficiency type 1 nuclear import. J Virol 70: 1027–1032
Han JJ et al (1999) Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. Hum Gene Ther 10: 1867–1873
Heinzinger NK et al (1994) The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc Natl Acad Sci USA 91: 7311–7315
Kafri T et al (1997) Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nature Gen 17: 314–317
Lewis PF, Emerman M (1994) Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J Virol 68: 510–516
Lewis PF, Hensel M, Emerman M (1992) Human immunodeficiency virus infection of cell arrested in the cell cycle. EMBO J 11: 3053–3058
Miyoshi H et al (1998) Development of a self-inactivating lentivirus vector. J Virol 72: 8150–8157
Miyoshi H et al (1999) Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science 283: 682–686
Miyoshi H, Takahashi M, Gage FH, Verma IM (1997) Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA 94: 10319–10323
Naldini L et al (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263–267
Olsen JC (1998) Gene transfer vectors derived from equine infectious anemia virus. Gene Ther 5: 1481–1487
Poeschla EF, Wong-Staal F, Looney DJ (1998) Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nature Med 4: 354–357
Roe T, Reynolds TC, Yu G, Brown PO (1993) Integration of murine leukemia virus DNA depends on mitosis. EMBO J 12: 2099–2108
Sutton R et al (1998) Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells. J Virol 72: 5781–5788
Sutton R, Uchida N, Brown P (1999) Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent. J Virol 73: 3649–3658
Takahashi M, Miyoshi H, Verme IM, Gage FH (1999) Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 73: 7812–7816
Uchida N et al (1998) HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proc Natl Acad Sci USA 95: 11939–11944
von Schwedler U, Kornbluth RS, Trono D (1994) The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T-lymphocytes. Proc Natl Acad Sci USA 91: 6992–6996
White SM et al (1999) Lentivirus vectors using human and simian immunodeficiency virus elements. J Virol 73: 2832–2940
Woods NB et al. (2000) Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. Blood, in press
Zufferey R et al (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 5: 871–875
Zufferey R et al (1998) Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 72: 9873–9880
Editor information
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Trono, D. (2001). Lentiviral Vectors for the Genetic Modification of Hematopoietic Stem Cells. In: Holzgreve, W., Lessl, M. (eds) Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy. Ernst Schering Research Foundation Workshop, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04469-8_2
Download citation
DOI: https://doi.org/10.1007/978-3-662-04469-8_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-04471-1
Online ISBN: 978-3-662-04469-8
eBook Packages: Springer Book Archive