Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease

  • J. R. Passweg
  • A. Gratwohl
  • A. Tyndall
Conference paper
Part of the Ernst Schering Research Foundation Workshop Supplement book series (SCHERING FOUND, volume 7)


Five years ago the concept of immunoablation with hematopoietic stem cell transplantation was still being discussed as a treatment option for severe autoimmune disease [1]. This has been preceded by data from animal models supporting such a concept [2]. By the end of 1999, data on 250 patients have been reported, with enough experience to say that in selected cases, an acceptable risk/benefit ratio exists to justify the commencement of prospective, comparative randomized trials to determine the place, if any, of such an expensive and toxic procedure in the treatment of severe autoimmune disease.


Multiple Sclerosis Hematopoietic Stem Cell Transplantation Systemic Sclerosis Allogeneic Hematopoietic Stem Cell Transplantation Mixed Connective Tissue Disease 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • J. R. Passweg
  • A. Gratwohl
  • A. Tyndall

There are no affiliations available

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