Abstract
Five years ago the concept of immunoablation with hematopoietic stem cell transplantation was still being discussed as a treatment option for severe autoimmune disease [1]. This has been preceded by data from animal models supporting such a concept [2]. By the end of 1999, data on 250 patients have been reported, with enough experience to say that in selected cases, an acceptable risk/benefit ratio exists to justify the commencement of prospective, comparative randomized trials to determine the place, if any, of such an expensive and toxic procedure in the treatment of severe autoimmune disease.
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Passweg, J.R., Gratwohl, A., Tyndall, A. (2001). Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease. In: Pozzilli, C., Pozzilli, P., Kapp, JF. (eds) New Concepts in Pathology and Treatment of Autoimmune Disorders. Ernst Schering Research Foundation Workshop Supplement, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04450-6_8
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DOI: https://doi.org/10.1007/978-3-662-04450-6_8
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