Drug Metabolism Assays and Their Use in Drug Discovery
Arguably the biggest challenge currently facing the global pharmaceutical industry is the urgent need for improvements in productivity in the discovery and development of new medicines. Improved productivity requires enhancements in both efficiency and effectiveness. Thus, in the context of drug discovery it involves a shortening of the time taken from lead identification to full development, but more importantly, a marked increase in the quality of drug candidates provided for development. The consequences of the past practice of taking sub-optimal compounds into development are all too apparent in the high attrition rate of drug candidates during this phase and the oft-repeated fact that the majority of the cost of bringing a new medicine to market is due to those failures (Abelson 1993).
KeywordsDrug Discovery Drug Candidate Metabolic Stability Lead Optimisation Poor Bioavailability
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