The Elderly and Hormone Replacement

  • F. Naftolin
  • T. Aso
  • À. Balogh
  • K. K. Limpaphayom
  • H. P. G. Schneider
  • J. H. Segars
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 8)


Prior to our roundtable there was already ample discussion of the reversal of the demographic trends in recent years. This has very profound implications for the aging population and was referred to at the beginning of our session; Dr. Landgren reminded us of the demographic shifts to aging population.


Estrogen Receptor Hormone Replacement Therapy Hormone Replacement Estrogen Action Menopausal Woman 
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  1. Bechmann I, Mor G, Nilsen J, Eliza M, Nitsch R, Naftolin F (1999) FasL (CD95L, ApolL) is expressed in the normal rat and human brain: Evidence for the existence of an Immunological Brain Barrier (IBB). Glia 27:62–74PubMedCrossRefGoogle Scholar
  2. Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F (1999) Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and humans. Menopause 6:21–28PubMedCrossRefGoogle Scholar
  3. Gutierrez LS, Eliza M, Niven-Fairchild, T, Naftolin F, Mor G (1999) The fas/fas-ligand system: a mechanism for immune evasion in human breast carcinomas. Breast Cancer Res Treat 54:245–253PubMedCrossRefGoogle Scholar
  4. Keefe D, Watson R, Naftolin F (1999) Hormone replacement therapy alleviates sleep apnea in menopausal women. Menopause 6:196–200PubMedCrossRefGoogle Scholar
  5. Mor G, Naftolin F (1998) Estrogen, menopause and the immune system. Journal of the British Menopause Society. Journal of the British Menopause Society 4 [Suppl S 1]:4–8Google Scholar
  6. Mor G, Yue W, Santen R, Gutierrez L, Eliza M, Berstein L, Harada N, Wang J, Lysiak J, Diano S, Naftolin F (1999) Macrophages, estrogen and the microenvironment of breast cancer. J Steroid Biochem Mol Biol 67:403–411CrossRefGoogle Scholar
  7. Naftolin F, Lavy G, Palumbo A, DeCherney AH (1988) Poissons, grenouilles, femmes et hommes: The appropriation and retention of archetypical systems for reproduction. Gynecol Endocrinol 2:265–273PubMedCrossRefGoogle Scholar
  8. Naftolin F, Whitten P, Keefe D (1994) An evolutionary perspective on the climateric and menopause. Menopause 4:223–225Google Scholar
  9. Naftolin F (1997) Menopause and Cognition: Short-Term Memory Impairment. Menopause Management 6:17–19Google Scholar
  10. Silva I, Mor G, Naftolin F (2000) Estrogen and the aging brain. Maturitas 38:95–101CrossRefGoogle Scholar
  11. ReferencesGoogle Scholar
  12. Aso T, Koyama T, Kaneko H, Seki M (1996) Alternative to hormone replacement therapy for menopausal management: possible role of Kampo medicine. In: Wren BG (ed) Progress in the Management of the Menopause. Parthenon, London, pp 71–77Google Scholar
  13. Aso T (1996) Reproductive health before and after childbearing age: the Japanese scene. Adv Contracept 12:305–308PubMedCrossRefGoogle Scholar
  14. Aso T (1997) Demography of the menopause and pattern of climacteric symptoms in the East Asian region. Ratnam SS, Campana A (eds) Proceedings of the first consensus meeting on menopause in the East Asian Region. Medical Forum International, pp 24–32Google Scholar
  15. Boulet MJ, Oddens BJ, Lehert P (1994) Climacteric and menopause in seven South-East Asian countries. Maturitas 19:157–176PubMedCrossRefGoogle Scholar
  16. Lock M (1993) Encounters with aging: mythologies of menopause in Japan and North America. University of California Press, BerkeleyGoogle Scholar
  17. Lock M (1997) Views of Japanese women on menopause: a discussion based on cultural differences with Canada and America. J Jap Menopause Soc 5:53–59Google Scholar
  18. Payer L (1991) International health report. Menopause in various cultures. A portrait of the menopause. Parthenon, LondonGoogle Scholar
  19. ReferencesGoogle Scholar
  20. 1.
    Zagorin A (1994) Real wealth of nations. Time 146(14):146Google Scholar
  21. 2.
    Oldenhave A, Netelenbos C (1994) Pathogenesis of the climacteric complaints: ready for the change? Lancet 343:649–653PubMedCrossRefGoogle Scholar
  22. 3.
    Balogh A, Bettembuk P (1997) Hormone replacement therapy and prevention of osteoporosis: risk assessment and practical advice. Eur J Obstet Gynecol Reprod Biol 71:189–191PubMedCrossRefGoogle Scholar
  23. 4.
    Diczfalusy E (1996) The third age, the Third World and the third millennium. Contraception 53:1–7PubMedCrossRefGoogle Scholar
  24. ReferencesGoogle Scholar
  25. 1.
    Diczfalusy E (1997) In search of human dignity: gender equity, reproductive health, and healthy aging. Int J Obstet Gynecol 59:195–206CrossRefGoogle Scholar
  26. 2.
    Diczfalusy E (1999) The past, present, and future. Int J Gynaecol Obstet 67:S 153—S 157Google Scholar
  27. 3.
    Diczfalusy E (2000) The contraceptive revolution. Contraception 61:3–7PubMedCrossRefGoogle Scholar
  28. 4.
    Beatson G (1896) Lancet 2:104–107CrossRefGoogle Scholar
  29. 5.
    Parker MG (1999) Transcriptional activation by oestrogen receptors. Biochem Soc Symp 63:45–50Google Scholar
  30. 6.
    Seiler-Tuyns A, Walker P, Martinez E, Merillat AM, Givel F, Wahli W (1986) Identification of estrogen-responsive DNA sequences by transient transfection in a human breast cancer cell line. Nuc Acids Res 14:8755–8770CrossRefGoogle Scholar
  31. 7.
    Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889–895PubMedCrossRefGoogle Scholar
  32. 8.
    Kuiper GGJ, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-A (1996) Cloning of a novel estrogen receptor expressed in rat prostate. Proc Natl Acad Sci USA 93:5925–5930PubMedCrossRefGoogle Scholar
  33. 9.
    Korach KS (1994) Insights from the study of animals lacking functional estrogen receptor. Science 266:1524–1527PubMedCrossRefGoogle Scholar
  34. 10.
    Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach K, Gustafsson J-A, Smithies O (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor b. Proc Natl Acad Sci USA 95:15677–15682PubMedCrossRefGoogle Scholar
  35. 11.
    Couse JF, Hewitt S, Bunch DO, Sar M, Walker VR, Davis BJ, Korach KS (1999) Postnatal sex reversal of the ovaries in mice lacking estrogen receptor a and b. Science 286:2328–2331PubMedCrossRefGoogle Scholar
  36. 12.
    Onate SA, Tsai ST, Tsai MJ, O’Malley B W (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354–1357PubMedCrossRefGoogle Scholar
  37. 13.
    Cavailles V, Dauvois S, Lopez G, Hoare S, Kushner PJ, Parker MG (1995) Nuclear factor RIP 140 modulates transcriptional activation by the estrogen receptor. EMBO J 14:3741–3751PubMedGoogle Scholar
  38. 14.
    Edwards DP (1999) Coregulatory proteins in nuclear receptor action. Vit Horm 55:165–219CrossRefGoogle Scholar
  39. 15.
    Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai M-J, O’Malley BW (1998) Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science 279:1922–1925PubMedCrossRefGoogle Scholar
  40. 16.
    Brzozowski AM, Pike W, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson J-A, Carlquist M (1997) Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389:753–757PubMedCrossRefGoogle Scholar
  41. 17.
    Muramatsu M, Inoue S (2000) Estrogen receptors: how do they control reproductive functions and nonreproductive functions? Biochem Biophys Res Comm 270:1–10PubMedCrossRefGoogle Scholar
  42. 18.
    Christ M, Haseroth K, Falkenstein E, Wehling M (1999) Nongenomic steroid actions: fact or fantasy? Vit Horm 57:325–373CrossRefGoogle Scholar
  43. 19.
    Aronica M, Katzenellenbogen B S (1993) Stimulation of estrogen receptormediated transcription and alteration in phosphorylation state of rat uterine ER by estrogen, cAMP, and IGF-1. Mol Endocrinol 7:743–752PubMedCrossRefGoogle Scholar
  44. 20.
    Cho H, Katzenellenbogen BS (1993) Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators. Mol Endocrinol 7:441–452PubMedCrossRefGoogle Scholar
  45. 21.
    Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J (1998) Characterization of Brx, a novel Dbl family member that modulates estrogen action. Oncogene 16:2513–2526PubMedCrossRefGoogle Scholar
  46. 22.
    Bunone G, Briand PA, Miksicek RJ, Picard D (1996) Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J 15:2174–2183PubMedGoogle Scholar
  47. 23.
    Thenot S, Charpin M, Bonnet S, Cavailles V (1999) Estrogen receptor cofactors expression in breast and endometrial human cancer cells. Mol Cell Endocrinol 156:85–93PubMedCrossRefGoogle Scholar
  48. 24.
    Grazzini E, Guillion G, Mouillac B, Zingg HH (1998) Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 392:509–512PubMedCrossRefGoogle Scholar
  49. 25.
    Mitlak BH, Cohen FJ (1997) In search of optimal long-term female hormone replacement: the potential of selective estrogen receptor modulators. Horm Res 48:155–163PubMedCrossRefGoogle Scholar
  50. 26.
    Leondires MP, Segars J, Walsh BW (1999) The use of antiestrogens in the postmenopausal woman. In: Seifer DB, Kennard EA (eds) Contemporary endocrinology. Menopause: endocrinology and management. Humana, Totowa, pp 179–207Google Scholar
  51. 27.
    Labrie F, Labrie C, Belanger A, Simard J, Gauthier S, Luu-The V, Merand Y, Giguere V, Candas B, Lou S, Martel C, Singh S, Fournier M, Coquet A, Richard V, Charbonneau R, Charpenet G, Tremblay A, Tremblay G, Cusan L, Veilleux R (1999) EM-652 (SCH 57068), a third generation SERM acting as a pure antiestrogen in the mammary gland and endometrium. J Steroid Biochem Mol Biol 69:51–84PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • F. Naftolin
  • T. Aso
  • À. Balogh
  • K. K. Limpaphayom
  • H. P. G. Schneider
  • J. H. Segars

There are no affiliations available

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