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Eph Receptors and Ephrins Are Key Regulators of Morphogenesis

  • Conference paper
Of Fish, Fly, Worm, and Man

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 29))

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Abstract

Morphogenesis is the creation of form during development. In all vertebrate embryos cells move and change shape in precise patterns at specific times to generate the tissues and layers of the forming body. The molecular basis of the control of morphogenesis is not well understood. The Eph receptors and their ligands the ephrins, represent a cellular signalling system that is important for the correct enactment of morpho-genetic processes in the vertebrate and invertebrate embryo. These proteins are known to be key players in a number of morphogenetic events in the vertebrate embryo including axon guidance in the developing nervous system, neural crest migration and segmentation of the paraxial mesoderm and the hindbrain region of the neural plate. This review outlines the evidence for these conclusions and focuses mainly, but not exclusively, on the role of Eph/ephrin signalling in the nervous system.

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Authors and Affiliations

  1. Department of Anatomy and Developmental Biology, University College London, UK

    Stephen Wilson

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  1. N. Holder
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  2. L. Durbin
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  3. J. Cooke
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  4. Stephen Wilson
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  1. Abteilung Genetik, Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35/III, 72076, Tübingen, Germany

    Christiane Nüsslein-Volhard

  2. Enabling Technologies, Preclinical Drug Research, Schering AG, Müllerstrasse 178, 13342, Berlin, Germany

    Jörn Krätzschmar

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Holder, N., Durbin, L., Cooke, J., Wilson, S. (2000). Eph Receptors and Ephrins Are Key Regulators of Morphogenesis. In: Nüsslein-Volhard, C., Krätzschmar, J. (eds) Of Fish, Fly, Worm, and Man. Ernst Schering Research Foundation Workshop, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04264-9_8

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  • DOI: https://doi.org/10.1007/978-3-662-04264-9_8

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