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Genetic Dissection of Heart Development

  • Conference paper
Of Fish, Fly, Worm, and Man

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 29))

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Abstract

Genetic analysis has been a powerful tool to identify genes and pathways in early patterning and cell fate determination in Drosophila and Caenorhabditis elegans (Nusslein-Volhard 1994). Lacking a vertebrate model system for large-scale genome-wide screens has limited a direct genetic approach toward vertebrate pattern formation in the past. Luckily, gene functions and pathways are often conserved from invertebrates to vertebrates and studying these pathways has been fruitful in understanding vertebrate pattern formation. Some of the best known examples include the role of the hox genes in patterning the vertebrate nervous system, the TGF-β family and wnt signaling pathways in dorsoventral patterning, and the hedgehog pathway in nervous system and limb patterning [for review see Pattern Formation during Development (1997) Cold Spring Harbor Symposium Quantum Biology, vol. 62].

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Authors
  1. J.-N. Chen
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  2. M. C. Fishman
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Editor information

Editors and Affiliations

  1. Abteilung Genetik, Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35/III, 72076, Tübingen, Germany

    Christiane Nüsslein-Volhard

  2. Enabling Technologies, Preclinical Drug Research, Schering AG, Müllerstrasse 178, 13342, Berlin, Germany

    Jörn Krätzschmar

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© 2000 Springer-Verlag Berlin Heidelberg

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Chen, JN., Fishman, M.C. (2000). Genetic Dissection of Heart Development. In: Nüsslein-Volhard, C., Krätzschmar, J. (eds) Of Fish, Fly, Worm, and Man. Ernst Schering Research Foundation Workshop, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04264-9_7

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  • DOI: https://doi.org/10.1007/978-3-662-04264-9_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-04266-3

  • Online ISBN: 978-3-662-04264-9

  • eBook Packages: Springer Book Archive

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