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Tumor Antigens

  • Conference paper
Book cover Therapeutic Vaccination Strategies

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 30))

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Abstract

With the immune surveillance hypothesis, Macfarlane Burnet summed up about one hundred years of development in tumor immunology. He collated evidence from numerous published reports and personal observations that document the crucial role of the immune system in the defense against cancer. This evidence has been complemented by new investigations and includes postmortem examinations that reveal a high incidence of malignancies that did not become clinically manifest, the demonstration of tumor infiltrating T lymphocytes in many malignancies which often are correlated with a favorable prognosis, spontaneous regression of tumors or tumor regression correlated with the induction of inflammation in the tumors, an increase of the incidence of cancer in patients who suffer from immune deficiency diseases, and, in experimental models, the increased frequency of cancer in thymectomized mice.

“In large long-lived animals, like most of the warm-blooded vertebrates, inheritable genetic changes must be common in somatic cells and a proportion of these changes will represent a step towards malignancy. It is an evolutionary necessity that there should be some mechanisms for eliminating or inactivating such potentially dangerous mutant cells ... The thymus-dependent system of immunocytes will be almost solely responsible for surveillance ...” (Burnet 1970)

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Authors
  1. P. Walden
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Editors and Affiliations

  1. Department of Dermatology and Allergy, Medical Faculty Charité, Humboldt University, Schumannstrasse 20/21, 10117, Berlin, Germany

    P. Walden  & W. Sterry  & 

  2. Experimental Dermatology, Schering AG, Müllerstrasse 178, 13342, Berlin, Germany

    H. Hennekes

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© 2000 Springer-Verlag Berlin Heidelberg

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Walden, P. (2000). Tumor Antigens. In: Walden, P., Sterry, W., Hennekes, H. (eds) Therapeutic Vaccination Strategies. Ernst Schering Research Foundation Workshop, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04183-3_2

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  • DOI: https://doi.org/10.1007/978-3-662-04183-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-04185-7

  • Online ISBN: 978-3-662-04183-3

  • eBook Packages: Springer Book Archive

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