Abstract
Hibernation-specific protein (HP) which was found in the blood of chipmunks (Tamias sibiricus asiaticus), a rodent hibernator, has been demonstrated to be downregulated by differential gene expression in the liver in association with an endogenous circannual rhythm. In the present paper, we investigated the existence and the structural properties of HP in cerebrospinal fluid (CSF) from the lateral ventricle. A much less amount of HP was detected in CSF in nonhibernating state. HP in CSF was markedly increased in association with a circannual rhythm of hibernation and structurally differed from HP in plasma. A similar increase in HP in CSF was induced by the administration of thyroxine that has been shown to cause the change in HP contents in plasma as seen during hibernation. These results suggested that HP plays a role in the brain during hibernation through structural changes. Thyroxine may be involved in the regulation of HP during hibernation.
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References
Andrews MT, Squire TL, Bowen CM, Rollins, MR (1998) Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal. Proc. Natl. Acad. Sci. USA 95: 8392–8397
Bitting L, Sutin EL, Watson FL, Leard LE, Ohara BF, Heller HC, Kilduff TS (1994) cc-Fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation. Neurosci Lett 165: 117–121
Boyer BB, Barnes BB, Lowell BB, Grujic, D (1998) Differential regulation of uncoupling protien gene homologues in multiple tissues of hibernating ground squirrels. Am J Physiol 275: R 1232-R 1238
Kondo N (1997) Physiological and Biochemical Studies on Hibernation Control Mechanism in Mammalian Hibernation. In: Hayaishi O, Inoue S (eds) Sleep and Sleep Disorders: From Molecular to Behavior. Academic Press, Tokyo, pp 129–143
Kondo J, Kondo N (1996) Structural aspects of comples of hibernation-specific proteins. In Adaptation to the cold: Tenth international hibernation symposium: 351–355
Kondo J, Kondo N (1996) Structural aspects of complex of hibernation-specific proteins (HP). In: Geiser F, Hulbert AJ, Nicol SC (eds) Aptation to the Cold: Tenth International Hibernation Symposium. University of New England Press, Armidale, pp 351–355
Kondo N, Shibata S (1984) Calcium source for excitation-contraction coupling in myocardium of nonhibernating and hibernating chipmunks. Science 225: 641–643
Ohtsu T, Kondo N (1996) Possoble regulation of hibernation-specific proteins in primary cultures of hepatocytes from chipmunks. In: Geiser F, Hulbert AJ, Nicol SC (eds) Aptation to the Cold: Tenth International Hibernation Symposium. University of New England Press, Armidale, pp 357–362
Ohtsu T, Sekijima T, Kondo N (1997) Effects of thyroxine on production of hibernation-specific proteins in chipmunk. Zool Sci 14(Suppl.): 17
Sallmen T, Beckman A., Stanton TL, Eriksson KS, Tarhanen J, Tuomisto L, Panula P (1999) Major changes in the brain histamine system of the ground squirrel Citellus lateralis during hibernation. J. Neurosci. 19(5), 1824–1835.
Sere HK, Wang LCH, Martin SL (1992) Cenral role for differential gene expression in mammalian hibernation. Proc Natl Acad Sci USA 89: 7119–7123
Soukri A, Valverde F, Hafin N, Elkebbaj MS, Serrano A (1996) Occurence of a differential expression of the glyceral dehyde-3-phosphate dehydrogenase gene in muscle and liver from euthermic and induced hibernating jerboa (Jaculus orientalis). Gene 181: 139–145
Takamatsu N, Ohba KI, Kondo J, Kondo N, Shiba T (1993) Hibernation-associated gene regulation of plasma proteins with a collagen-like domain in mammalian hibernators. Mol Cell Biol 13: 1516–1521
Wang LCH (1982) Hibernation and the endocrine. In: Lyman CP, Willis JS, Malan A, Wang LCH (eds) Hibernation and Torpor in Mammals and Birds. Academic Press, New York, pp 206–236
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Sekijima, T., Kondo, J., Ohtsu, T., Kondo, N. (2000). Endogenous Changes in Hibernation-specific Protein in Chipmunk Cerebrospinal Fluid. In: Heldmaier, G., Klingenspor, M. (eds) Life in the Cold. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04162-8_40
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DOI: https://doi.org/10.1007/978-3-662-04162-8_40
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