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Metabolic and Storage Diseases

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Bone Diseases
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Abstract

Disorders of metabolism, which are bound up with the storage of physiological substances, can also bring about changes in the skeleton. These substances are mostly stored in the cells of the reticulo-histiocytic system, which is significantly activated. For this reason the pathological storage foci in the bone are mostly found in the marrow cavity. Here they destroy the cancellous trabeculae, producing a reactive osteoporosis and often leading to localized bone necroses. This bone destruction is seen in the radiograph as an irregular patchy osteolysis. Since they are systemic diseases, several lesions in several different bones usually appear. Apart from the bones, other tissues and parenchymatous organs may be involved, and this can cause functional disorders.

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Adler, CP. (2000). Metabolic and Storage Diseases. In: Bone Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04088-1_9

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  • DOI: https://doi.org/10.1007/978-3-662-04088-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-08450-8

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