Bone Diseases pp 183-193 | Cite as

Metabolic and Storage Diseases

  • Claus-Peter Adler


Disorders of metabolism, which are bound up with the storage of physiological substances, can also bring about changes in the skeleton. These substances are mostly stored in the cells of the reticulo-histiocytic system, which is significantly activated. For this reason the pathological storage foci in the bone are mostly found in the marrow cavity. Here they destroy the cancellous trabeculae, producing a reactive osteoporosis and often leading to localized bone necroses. This bone destruction is seen in the radiograph as an irregular patchy osteolysis. Since they are systemic diseases, several lesions in several different bones usually appear. Apart from the bones, other tissues and parenchymatous organs may be involved, and this can cause functional disorders.


Storage Disease Marrow Cavity Foreign Body Giant Cell Anterior Longitudinal Ligament Urate Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Claus-Peter Adler
    • 1
  1. 1.Pathologisches Institut Ludwig-Aschoff-Haus, Referenzzentrum für KnochenkrankheitenUniversität FreiburgFreiburgGermany

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