Regulatory Mechanisms in Mammalian Spermatogenesis

  • D. M. de Kretser
  • T. Meehan
  • M. K. O’Bryan
  • N. G. Wreford
  • R. I. McLachlan
  • K. L. Loveland
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 6)


The output of spermatozoa by the testis is carefully regulated through a number of mechanisms that ultimately determine the proliferation and survival of germ cells. Because of the intimate relationship of the germ cells to the supporting cells, termed Sertoli cells, any review of the regulatory mechanisms cannot proceed without considering their effects on the Sertoli cells. The links between the cell types are considerable and well beyond the scope of this chapter but are covered in several reviews(Bardin et al 1994; Russell & Griswold 1993). Consequently this chapter reviews the classical concepts concerning the hormonal regulation of spermatogenesis but also considers key aspects of the physiology of the Sertoli cells. While the emphasis concerns the proliferation of germ cells, the review briefly considers the process of apoptosis because the survival of germ cells depends on the balance between these processes.


Germ Cell Androgen Receptor Sertoli Cell Stem Cell Factor Primordial Germ Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • D. M. de Kretser
  • T. Meehan
  • M. K. O’Bryan
  • N. G. Wreford
  • R. I. McLachlan
  • K. L. Loveland

There are no affiliations available

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