Recruitment of p160 Coactivators to Androgen Receptors
Androgens control the proliferation of target cells and a number of physiological responses by means of receptors that function as ligand-dependent transcription factors. Androgen receptors (AR) function either directly by binding to response elements in the vicinity of the promoter or indirectly by modulating the activity of other transcription factors. In common with other nuclear receptors the AR is likely to undergo a characteristic conformational change upon ligand binding that allows the recruitment of cofactors which are required to stimulate transcription of target genes [1, 2, 3]. It first became obvious that nuclear receptors require common cofactors to activate transcription when “squelching” between different receptors was observed: the expression of one active receptor inhibited the activity of a second, implying the existence of an essential limiting cofactor .
KeywordsEstrogen Glutamine Tamoxifen Androgen Acetyl
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