Genetic Selection as a Tool in Mechanistic Enzymology and Protein Design

  • D. Hilvert
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 32)


Protein design is a challenging problem. We do not fully understand the rules of protein folding, and our knowledge of structure-function relationships in these macromolecules is at best incomplete. It is consequently not yet possible to specify the sequence of a polypeptide with any reasonable expectation that it will adopt a unique tertiary fold, much less recognize another molecule with high selectivity or catalyze a chemical reaction.


Protein Design Ether Oxygen Hydrogen Bonding Distance Catalytic Antibody Claisen Rearrangement 
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© Springer-Verlag Berlin Heidelberg 2000

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  • D. Hilvert

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