Genetic Selection as a Tool in Mechanistic Enzymology and Protein Design
Protein design is a challenging problem. We do not fully understand the rules of protein folding, and our knowledge of structure-function relationships in these macromolecules is at best incomplete. It is consequently not yet possible to specify the sequence of a polypeptide with any reasonable expectation that it will adopt a unique tertiary fold, much less recognize another molecule with high selectivity or catalyze a chemical reaction.
KeywordsTyrosine Catalysis Sedimentation Phenyl Proline
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