Erythema Multiforme

  • F. M. Brandao


Erythema multiforme (EM) is a distinctive cutaneous reaction to different stimuli, characterized by typical target lesions with an acral distribution, sometimes with mucosal lesions and systemic involvement, with a self-limited course and a recurrent tendency. Young male adults are most commonly affected, and an association with HLA B15 and DQW3 has been reported.


Erythema exudativum Multiforme 


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  1. 1.
    Champion RH (1992) Erythema multiforme. In: Rook, Wilkinson, Ebling (eds) Textbook of dermatology, 5th edn. Blackwell Scientific, Oxford, pp 1834–1838Google Scholar
  2. 2.
    Jorizzo JL (1992) Erythema multiforme. In: Moschella SL, Hurley HJ (1992) Dermatology, 3rd edn. Saunders, Philadelphia, pp 580–583Google Scholar
  3. 3.
    Renfro L, Grant Kels JM, Feder HM Jr, Daman LA (1989) Controversy: are systemic steroids indicated in the treatment of erythema multiforme? Pediat Dermatol 6: 43–50CrossRefGoogle Scholar
  4. 4.
    Patterson R, Dykewicz MS, Gonzalez A, Grammer LC, Green D, Greenberger PA, McGrath KG, Walker CL (1990) Erythema multiforme and Stevens-Johnson syndrome. Descriptive and therapeutic controversy. Chest 98: 331–336Google Scholar
  5. 5.
    Lozada-Nur F, Miranda C, Makiksi R (1994) Double blind clinical trial of 0.05% clobetasol propionate ointment in orabase and 0.05% fluocinonide in orabase in the treatment of patients with oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol 77: 598–604PubMedCrossRefGoogle Scholar
  6. 6.
    Huff JC (1988) Therapy and prevention of erytheme multiforme with acyclovir. Semin Dermatol 7: 212–217PubMedGoogle Scholar
  7. 7.
    Tatnall FM, Schofield JK, Leigh IM (1995) A double blind, placebo controlled trial of continuous acyclovir therapy in recurrent erythema multiforme. Br J Dermatol 132: 267–270PubMedCrossRefGoogle Scholar
  8. 8.
    Cheronati K, Claudy A, Souteyrand P, Cambazard F, Vaillant L, Moulin G, Crickx B, Morel P, Lamorelle A, Revuz J (1996) Traitement par thalidomide de l’erythème polymorphe chronique formes recidivantes et subintrantes. Etude rétrospective de 26 malades. Ann Dermatol Venereol 123: 375–377Google Scholar
  9. 9.
    Eastham JH, Segal JL, Gomez MF, Cole GW (1996) Reversal of erythema multiforme major with cyclophosphamide and prednisone. Ann Pharmather 30: 606–607Google Scholar

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© Springer-Verlag Berlin Heidelberg 2000

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  • F. M. Brandao

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