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The ER/AP1 Pathway: A Window on the Cell-Specific Estrogen-like Effects of Antiestrogens

  • Conference paper
Molecular Basis of Sex Hormone Receptor Function

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 24))

Abstract

We study an unusual pathway of estrogen receptor (ER) action, in which ER indirectly alters the transactivation capacity of the jun/fos complex (AP1 proteins), rather than stimulating gene expression by directly binding DNA. Here, we review the rationale for studying this pathway and the reasons for thinking that elucidation of ER/AP1 interactions will help us design the next generation of antiestrogens and hormone replacement therapies.

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Authors
  1. P. Webb
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  2. M.-R. Keneally
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  3. J. Shinsako
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  4. R. Uht
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  5. C. Anderson
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  6. K. Paech
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  7. T. S. Scanlan
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  8. P. J. Kushner
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Editor information

Editors and Affiliations

  1. Institute of Genetics and Molecular and Cell Biology, Parc d’Innovation, 1, rue Laurent Fries, B.P. 163, 67404, Illkirch Cedex, France

    H. Gronemeyer

  2. Fertility Control and Hormone Therapy, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    U. Fuhrmann

  3. Experimental Oncology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    K. Parczyk

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© 1998 Springer-Verlag Berlin Heidelberg

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Webb, P. et al. (1998). The ER/AP1 Pathway: A Window on the Cell-Specific Estrogen-like Effects of Antiestrogens. In: Gronemeyer, H., Fuhrmann, U., Parczyk, K. (eds) Molecular Basis of Sex Hormone Receptor Function. Ernst Schering Research Foundation Workshop, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03689-1_7

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  • DOI: https://doi.org/10.1007/978-3-662-03689-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03691-4

  • Online ISBN: 978-3-662-03689-1

  • eBook Packages: Springer Book Archive

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