The ER/AP1 Pathway: A Window on the Cell-Specific Estrogen-like Effects of Antiestrogens

  • P. Webb
  • M.-R. Keneally
  • J. Shinsako
  • R. Uht
  • C. Anderson
  • K. Paech
  • T. S. Scanlan
  • P. J. Kushner
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 24)


We study an unusual pathway of estrogen receptor (ER) action, in which ER indirectly alters the transactivation capacity of the jun/fos complex (AP1 proteins), rather than stimulating gene expression by directly binding DNA. Here, we review the rationale for studying this pathway and the reasons for thinking that elucidation of ER/AP1 interactions will help us design the next generation of antiestrogens and hormone replacement therapies.


Estrogen Receptor MCF7 Cell Estrogen Response Element Ishikawa Cell Antiestrogen Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • P. Webb
  • M.-R. Keneally
  • J. Shinsako
  • R. Uht
  • C. Anderson
  • K. Paech
  • T. S. Scanlan
  • P. J. Kushner

There are no affiliations available

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