Skip to main content

A Search for a Mechanism for the Antiinflammatory Action of Glucocorticoids

  • Conference paper
Molecular Basis of Sex Hormone Receptor Function

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 24))

  • 55 Accesses

Abstract

Cortisol, a glucocorticoid hormone, was first isolated from adrenal tissues in 1936 (Mason et al. 1936a,b) and about 10 years later it was shown to be effective in the treatment of rheumatoid arthritis, particularly when administered pharmacologically (Hench et al. 1949, 1950).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abbinante-Nissen JM, Simpson LG, Leikauf GD (1995) Corticosteroids increase secretory leukocytes protease inhibitor transcript levels in airway epithelial cells. Am J Physiol 268: L601–L606

    PubMed  CAS  Google Scholar 

  • Akira S, Kishimoto T (1992) IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev 127: 25–50

    Article  PubMed  CAS  Google Scholar 

  • Alam T, An MR, Mifflin RC, Hsieh C-C, Ge X, Papaconstantinou J (1993) trans-activation of the al-acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor. J Biol Chem 268: 15681–15688

    Google Scholar 

  • Amano Y, Lee SW, Allison AC (1993) Inhibition by glucocorticoids of the formation of interleukin-la, interleukin-lß and interleukin 6: mediation by decreased mRNA stability. Mol Pharmacol 43: 176–182

    PubMed  CAS  Google Scholar 

  • Bacus E, Andris F, Dubois PM, Urbain J, Leo 0 (1996) Dexamethasone inhibits the early steps of antigen receptor signaling in activated T lymphocytes. J Immunol 156: 4555–4561

    Google Scholar 

  • Baeuerle OA, Henkel T (1994) Function and activation of NFkB in the immune system. Annu Rev Immunol 12: 141–179

    Article  PubMed  CAS  Google Scholar 

  • Baumann H, Firestone GL, Burgess TL, Grosse KW, Yamamoto KR, Held WA (1983) Dexamethasone regulation of al-acid glycoprotein and the other acute phase reactants in rat liver and hepatoma cells. J Biol Chem 253: 563–570

    Google Scholar 

  • Berger M (1991) Inflammation in the lung in cystic fibrosis. A vicious cycle that does more harm than good? Clin Rev Allergy 9: 119–142

    PubMed  CAS  Google Scholar 

  • Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A (1986) Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232: 977–980

    Article  PubMed  CAS  Google Scholar 

  • Boumpas DT, Anastassion ED, Older SA, Tsokos GC, Nelson DL, Balow JE (1991) Dexmethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J Clin Invest 87: 1739–1747

    Article  PubMed  CAS  Google Scholar 

  • Caelles C, Gonzales-Sancho J, Munoz A (1997) Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev 11: 3351–3364

    Article  PubMed  CAS  Google Scholar 

  • Caldenhoven E, Liden J, Wissink S, van de Solpe A, Raaijmakers J, Koenderman L, Okret S, Gustafsson J-a, van der Saag PT (1995) Negative crosstalk between Rel A and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 9: 401–412

    Article  PubMed  CAS  Google Scholar 

  • Cato ACB, Wade E (1996) Molecular mechanisms of anti-inflammatory action of glucocorticoids. Bioessays 18: 371–378

    Article  PubMed  CAS  Google Scholar 

  • Celada A, McKercher S, Maki RA (1993) Repression of major histocompatibility complex 1 A expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein. J Exp Med 177: 691–698

    Article  PubMed  CAS  Google Scholar 

  • Chen X-S, Sheller JR, Johnson EN, Funk CD (1994) Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 372: 179–182

    Article  PubMed  CAS  Google Scholar 

  • Chou MM, Blenis J (1995) The 70-kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signaling. Curr Opin Cell Biol 7: 806–814

    Article  PubMed  CAS  Google Scholar 

  • Chuvpilo S, Schomberg C, Gerwig R, Heinfling A, Reeves R, Grummt F, Serfling E (1993) Multiple closely-linked NFAT/octamer and HMGI(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res 21: 5694–5704

    Article  PubMed  CAS  Google Scholar 

  • Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G (1992) A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule I and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 89: 9991–9995

    Article  PubMed  CAS  Google Scholar 

  • De Lucas LG, Johnson DR, Whitley MZ, Collins T, Pober JS (1994) cAMP and tumor necrosis factor competitively regulate transcriptional activation through the nuclear factor binding to the c-AMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 ( E-selectin) promoter. J Biol Chem 269: 19193–19196

    Google Scholar 

  • Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249: 1266–1272

    Article  PubMed  CAS  Google Scholar 

  • Flower RJ, Rothwell NJ (1994) Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol Sci 15: 71–76

    Article  PubMed  CAS  Google Scholar 

  • Fryksmark U, Prellner T, Tegner H, Ohlsson K (1984) Studies on the role of antileukoprotease in respiratory tract disease. Eur J Respir Dis 65: 201–209

    PubMed  CAS  Google Scholar 

  • Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH (1994) Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci USA 91: 12852–12856

    Article  PubMed  CAS  Google Scholar 

  • Griffiths RJ, Smith MA, Roach ML, Stock IL, Stam EJ, Milici AJ, Scampoli DN, Eskra JD, Byrum RS, Koller BH, McNeish JD (1997) Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient mice. J Exp Med 185: 1123–1129

    Article  PubMed  CAS  Google Scholar 

  • Han J, Thompson P, Beutler B (1990) Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. J Exp Med 172: 391–394

    Article  PubMed  CAS  Google Scholar 

  • Hattori M, Abraham LJ, Northemann W, Fey GH (1990) Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat a2-macroglobulin gene. Proc Natl Acad Sci USA 87: 2364–2368

    Article  PubMed  CAS  Google Scholar 

  • Heck S, Bender K, Kullmann M, Göttlicher M, Herrlich P, Cato ACB (1997) IxBa-independnet downregulation of NF-KB activity by glucocorticoids. EMBO J 16: 4698–4707

    Google Scholar 

  • Hench PS, Kendall EC, Slocumb CH, Polley HF (1949) The effect of a hormone of the adrenal cortex (17-hydroxy-1l-dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc Staff Meet Mayo Clin Proc 24: 181–197

    CAS  Google Scholar 

  • Hench PS, Kendall EC, Slocumb CH, Polley HF (1950) Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatoid fever and certain other conditions. Arch Intern Med 85: 545–666

    Article  CAS  Google Scholar 

  • Huhtala P, Tuuttila A, Chow LT, Lohi J, Keski-Oja J, Tryggvason K (1991) Complete structure of the human gene for 92-kDa type IV collagenase. J Biol Chem 266: 16485–16490

    PubMed  CAS  Google Scholar 

  • Jonat C, Rahmsdorf HJ, Park KK, Cato ACB, Gebel S, Ponta H, Herrlich P (1990) Antitumor production and antiinflammation: downregulation of API ( Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1182–1204

    Google Scholar 

  • Jonat C, Stein B, Ponta H, Herrlich P, Rahmsdorf HJ (1992) Positive and negative regulation of collagenase gene expression. Matrix 1: 145–155

    PubMed  CAS  Google Scholar 

  • Kennedy BP, Diehl R, Boie Y, Adam M, Dixon RF (1991) Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein ( FLAP ). J Biol Chem 256: 8511–8516

    Google Scholar 

  • Kida K, Mizuuchi T, Takeyama K, Hiratsuka T, Jinno K, Hosoda A, Imaizumi A, Suzuki Y (1992) Serum secretory leukoprotease inhibitor levels to diagnose pneumonia in elderly. Am Rev Respir Dis 146: 1426–1429

    PubMed  CAS  Google Scholar 

  • Kleinert H, Euchenhofer C, Ihrig-Biedert I, Förstermann U (1996) Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-KB. Mol Pharmacol 49: 15–21

    PubMed  CAS  Google Scholar 

  • König H, Ponta H, Rahmdorf HJ, Herrlich P (1992) Interference betwen pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. Embo J 11: 2241–2246

    PubMed  Google Scholar 

  • Koretzky GA (1997) The role of Grb2-associated proteins in T-cell activation. Immunol Today 18: 401–406

    Article  PubMed  CAS  Google Scholar 

  • Kunz D, Walker G, Eberhardt W, Pfeilschifter J (1996) Molecular mechanism of dexamethasone inhibition of nitric oxide synthase expression in interleukin 113-stimulated mesangial cells: evidence for the involvement of transcription and posttranscriptional regulation. Proc Natl Acad Sci USA 93: 255–259

    Article  PubMed  CAS  Google Scholar 

  • Kushner I (1982) The phenomenon of the acute phase response. Ann NY Acad Sci 389: 39–48

    Article  PubMed  CAS  Google Scholar 

  • Kwon OJ, Jose PJ, Robbins RA, Schall TJ, Williams PJ (1995) Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am J Respir Cell Mol Biol 12: 488–496

    PubMed  CAS  Google Scholar 

  • Lai J-H, Tan T-H (1994) CD28 signaling causes a sustained downregulation of IiBa which can be prevented by the immunosuppressant mycin. J Biol Chem 269: 30077–30080

    Google Scholar 

  • Landemarco MF, McQuillan JJ, Rosen GD, Dean DC (1992) Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1). J Cell Biol 267: 16323–16329

    Google Scholar 

  • Lee SW, Tsou A-P, Chan H, Thomas J, Petrie K, Eugui EM, Allison AC (1988) Glucocorticoids selectively inhibit the transcription of the interleukin 1β gene and decrease the stability of interleukin 1β mRNA. Proc Natl Acad Sci USA 85: 1204–1208

    Article  PubMed  CAS  Google Scholar 

  • Lewis H, Kaszubska W, Delamarter JF, Whelan J (1994) Cooperativity between the two NF-KB complexes, mediated by high-mobility group protein I(Y) is essential for cytokine-induced expression of E-selectin promoter. Mol Cell Biol 14: 5701–5709

    Article  PubMed  CAS  Google Scholar 

  • Lewis RA, Austen KF, Soberman RJ (1990) Leukotrienes and other products of the 5-lipoxygenase pathway. N Engl J Med 323: 645–655

    Article  PubMed  CAS  Google Scholar 

  • Lukert BP, Raisz LG (1990) Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 112: 352–364

    PubMed  CAS  Google Scholar 

  • Mason HL, Myers CS, Kendall EC (1936a) The chemistry of crystalline substance isolated from the suprarenal gland. J Biol Chem 114: 613–631

    CAS  Google Scholar 

  • Mason HL, Myers CS, Kendall EC (1936b) Chemical studies of the suprarenal cortex. The identification of a substance which possesses the qualitative action of cortin. J Biol Chem 116: 267–276

    Google Scholar 

  • Maruyama M, Hay JG, Yoshimura K, Chu C-S, Crystal RG (1994) Modulation of secretory leukoprotease inhibitor gene expression in human brochial epithelial cells by phobol ester. J Clin Invest 94: 368–375

    Article  PubMed  CAS  Google Scholar 

  • McMillan RM, Walker ERH (1992) Designing therapeutically effective 5lipoxygenase inhibitors. Trends Pharmacol Sci 13: 323–330

    Article  PubMed  CAS  Google Scholar 

  • Mitchell JA, Belvisi MG, Akarasereenont P, Robbins RA, Jung-Kwon O, Croxtall J, Barnes PJ, Vane JR (1994) Induction of cyclo-oxygenase-2 by cytokines in human epithelial cells: regulation by dexamethasone. Br J Pharmacol 113: 1008–1014

    Article  PubMed  CAS  Google Scholar 

  • Moncada S, Higgs A (1993) The 1-arginine-nitric oxide pathway. N Engl J Med 329: 2002–2012

    Article  PubMed  CAS  Google Scholar 

  • Monfar M, Blenis J (1996) Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. Mol Endocrinol 10: 1107–1115

    Article  PubMed  CAS  Google Scholar 

  • Mori A, Kaminuma O, Suko M, Inoue S, Ohmura T, Hoshino A, Asakura Y, Miyazawa K, Yokota T, Okumura Y, Okudaira H (1997) Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids. Blood 89: 2891–2900

    PubMed  CAS  Google Scholar 

  • Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, Kasahara T, Matsushima K (1994) Novel mechanism of glucocorticoid-mediated gene repression. J Biol Chem 269: 13289–13295

    PubMed  CAS  Google Scholar 

  • Nathan C (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J 6: 3051–3064

    Google Scholar 

  • Nelson PJ, Ortiz BD, Pattison JM, Krensky AM (1996) Identification of a novel regulatory region critical for expression of the RANTES chemokine in activated T lymphocytes. J Immunol 157: 1139–1148

    PubMed  CAS  Google Scholar 

  • Neurath MF, Pettersson S, Meyer zum Büschenfelde K-H, Stober W (1996) Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-KB abrogates established experimental colitis in mice. Nat Med 2: 998–1004

    Article  PubMed  CAS  Google Scholar 

  • Nishio Y, Isshiki H, Kishimoto T, Akira S (1993) A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat al-acid glycoprotein gene via direct protein—protein interaction. Mol Cell Biol 13: 1854–1862

    PubMed  CAS  Google Scholar 

  • O’Banion MK, Winn VD, Young DA (1992) cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 89: 4888–4892

    Google Scholar 

  • Ohlsson K, Sveger T, Svenningson N (1992) Protease inhibitors in bronchoalveolar lavage fluid from neonates with special reference to secretory leukocyte protease inhibitor. Acta Paediatr 81: 757–759

    Article  PubMed  CAS  Google Scholar 

  • Ohtsuka T, Kubota A, Hirano T, Watanabe K, Yoshida H, Tsurutuji M, Iizuka Y, Konishi K, Tsurufuji S (1996) Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-KB activation. J Biol Chem 272: 1651–1659

    Google Scholar 

  • Oikarinen A, Kylmäniemi M, Autio-Harmainen H, Autio P, Salo T (1993) Demonstration of 72-kDa and 92-kDa forms of type IV collagenase in human skin: variable expression in various blistering diseases, induction during re-epithelialization, and decrease by topical glucocorticoids. J Invest Dermatol 101: 205–210

    Article  PubMed  CAS  Google Scholar 

  • Okamoto S, Mukaida N, Yasumoto K, Rice N, Ishikawa Y, Horiguchi H, Marakami S, Matsushima K (1994) The interleukin-8 AP-1 and KB-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. J Biol Chem 269: 8582–8589

    PubMed  CAS  Google Scholar 

  • Ortiz BD, Krensky AM, Nelson PJ (1996) Kinetics of transcription factors regulating the RANTES chemokine gene reveal a developmental switch in nuclear events during T-lymphocyte maturation. Mol Cell Biol 16: 202–210

    PubMed  CAS  Google Scholar 

  • Pai S-Y, Calvo V, Wood M, Bierer BE (1994) Cross-linking CD28 leads to activation of 70-kDa S6 kinase. Eur J Immunol 24: 2364–2368

    Article  PubMed  CAS  Google Scholar 

  • Paliogianni F, Ahuja SS, Balow JP, Balow JE, Boumpas DT (1993a) Novel mechanism for inhibition of human T cells by glucocorticoids. Glucocorticoids inhibit signal transduction through IL-2 receptor. J Immunol 151: 4081–4089

    PubMed  CAS  Google Scholar 

  • Paliogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT (19936) Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J Clin Invest 91: 1481–1489

    Google Scholar 

  • Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, Gerritsen ME (1997) Novel inhibitors of cytokine-induced IKB z phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effect in vivo. J Biol Chem 272: 21096–21103

    Article  PubMed  CAS  Google Scholar 

  • Piper JM, Ray WA, Daugherty MS, Griffin MR (1991) Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 114: 735–740

    PubMed  CAS  Google Scholar 

  • Pitzalis C, Pipitone N, Bajocchi G, Hall M, Goulding N, Lee A, Kingsley G, Lanchbury J, Panayi G (1997) Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion. An additional mechanism for their anti-inflammatory and immunosuppressive effect. J Immunol 158: 5007–5016

    Google Scholar 

  • Radomski NW, Palmer RMJ, Mancada S (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87: 10043–10047

    Article  PubMed  CAS  Google Scholar 

  • Ray A, Prefontaine KE (1994) Physical association and functional antagonism between the p65 subunit of transcription factor NF-KB and the glucocorticoid receptor. Proc Natl Acad Sci USA 91: 752–756

    Article  PubMed  CAS  Google Scholar 

  • Ray A, Laforge KS, Sehgal PB (1991) Repressor to activator switch by mutations in the first Zn finger of the glucocorticoid receptor: is direct DNA binding necessary? Proc Natl Acad Sci USA 88: 7086–7090

    Article  PubMed  CAS  Google Scholar 

  • Rao A, Luo C, Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15: 707–747

    Article  PubMed  CAS  Google Scholar 

  • Riddick CA, Ring WL, Baker JR, Hodulik CR, Bigby TD (1997) Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells. Eur J Biochem 246: 112–118

    Article  PubMed  CAS  Google Scholar 

  • Rider LG, Hirasawa N, Santini F, Beaven MA (1996) Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells. J Immunol 157: 2374–2380

    PubMed  CAS  Google Scholar 

  • Samuelsson B (1993) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220: 568–575

    Article  Google Scholar 

  • Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS Jr (1995) Characterization of mechanisms involved in transrepression of NF-KB by activated glucocorticoid receptors. Mol Cell Biol 15: 943–953

    PubMed  CAS  Google Scholar 

  • Schindler U, Baichwal VR (1994) Three NF-KB binding sites in the human ESelectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol Cell Biol 14: 5820–5831

    Article  PubMed  CAS  Google Scholar 

  • Simmons WW, Ungureanu-Longrois D, Smith GK, Smith TW, Kelley RA (1996) Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and 1-arginine transport. J Biol Chem 271: 23928–23937

    Article  PubMed  CAS  Google Scholar 

  • Solito E, Raugei G, Meli M, Parenti L (1991) Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells. FEBS Lett 291: 238–244

    Article  PubMed  CAS  Google Scholar 

  • Stein B, Yang MX (1995) Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-KB and c/EBP[3. Mol Cell Biol 15: 4971–4979

    PubMed  CAS  Google Scholar 

  • Stockley RA, Morrison HM, Kramps JA, Dijkman JH, Burnett D (1986) Elastase inhibitors of sputum sol phase: variability, relationship to neutrophil elastase inhibition and effect of corticosteroid treatment. Thorax 41: 442–447

    Article  PubMed  CAS  Google Scholar 

  • Swantek JL, Cobb MH, Geppert TD (1997) Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-a) translation: glucocorticoid inhibits TNF-a translation by blocking JNK/SAPK. Mol Cell Biol 17: 6274–6282

    PubMed  CAS  Google Scholar 

  • Szabo SJ, Gold JS, Murphy TL, Murphy KM (1993) Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: role for NF-Y and NF-ATc. Mol Cell Biol 13: 4793–4805

    PubMed  CAS  Google Scholar 

  • Thanos D, Maniatis T (1992) The high mobility group protein HMGI(Y) is required for NF-KB-dependent virus induction of the IFN-(3 gene. Cell 71: 777–789

    Article  PubMed  CAS  Google Scholar 

  • Tobler A, Meier R, Seitz M, Dewald B, Baggiolini M, Fey MF (1992) Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8 and IL-6, but not of M-CSF in human fibroblasts. Blood 79: 45–51

    PubMed  CAS  Google Scholar 

  • Vacca A, Felli MP, Farina AR, Martinotti S, Maroder M, Screpanti I, Meco D, Petrangeli E, Frati L, Gulino A (1992) Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements. J Exp Med 175: 637–646

    Article  PubMed  CAS  Google Scholar 

  • van de Solpe A, Caldenhoven E, Stade BG, Koenderman L, Raaijmakers JAM, Johnson JP, van der Saag PT (1994) 12-O-Tetradecanoylphorbol-13-acetate-and tumor necrosis factor-a-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human adhesion molecule-1 promoter. J Biol Chem 269: 6185–6192

    Google Scholar 

  • Vayssière BM, Dupont S, Choquait A, Petit F, Garcia T, Marchandeau C, Gronemeyer H, Resche-Rigon M (1997) Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. Mol Endocrinol 11: 1245–1255

    Article  PubMed  Google Scholar 

  • Walker G, Pfeilschifter J, Kunz D (1997) Mechanisms of suppression of inducible nitric-oxide synthase (iNOS) expression in interferon (IFN)-y-stimulated RAW 264.7 cells by dexamethasone. Evidence for the glucocorticoidinduced degradation of iNOS protein by calpain as a key step in post-transcriptional regulation. J Biol Chem 272: 16679–16687

    Google Scholar 

  • Whitley MZ, Thanos D, Read MA, Maniatis T, Collins T (1994) A striking similarity in the organization of the E-selectin and the beta interferon gene promoters. Mol Cell Biol 14: 6464–6475

    PubMed  CAS  Google Scholar 

  • Wingett D, Forcier K, Nielson CP (1996) Glucocorticoid-mediated inhibition of RANTES expression in human T lymphocytes. FEBS Lett 398: 308–311

    Article  PubMed  CAS  Google Scholar 

  • Xie Q-W, Kashiwabara Y, Nathan C (1994) Role of transcription factor Nfkb/Rel in induction of nitric oxide synthase. J Biol Chem 269: 4705–4708

    PubMed  CAS  Google Scholar 

  • Yamamoto K, Arakawa T, Ueda N, Yamamoto S (1995) Transcriptional role of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cycloxygenase-2 in MC3T3–E1 cells. J Biol Chem 270: 31315–31320

    Article  PubMed  CAS  Google Scholar 

  • Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M (1990) Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62: 1205–1215

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Cato, A.C.B. (1998). A Search for a Mechanism for the Antiinflammatory Action of Glucocorticoids. In: Gronemeyer, H., Fuhrmann, U., Parczyk, K. (eds) Molecular Basis of Sex Hormone Receptor Function. Ernst Schering Research Foundation Workshop, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03689-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-03689-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03691-4

  • Online ISBN: 978-3-662-03689-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics