Skip to main content
SpringerLink
Log in

The Control of Testis ACE Expression

  • Conference paper
Testicular Function: From Gene Expression to Genetic Manipulation

Part of the book series: Ernst Schering Research Foundation Workshop ((3368,volume 3))

Abstract

The renin-angiotensin system was first discovered by Tigerstedt and Bergman in 1898. These experiments, and the work of Goldblatt et al. in 1934, investigated the role of the renin-angiotensin system in blood pressure control. Since then many laboratories have described the biochemistry by which the protein angiotensinogen is converted into the eight amino acid peptide angiotensin II. The final step in this process, the conversion of the decapeptide precursor angiotensin I into angiotensin II, is catalyzed by angiotensin-converting enzyme (ACE), a dipeptidyl carboxypeptidase (Corvol et al. 1995).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bernstein KE, Martin BM, Edwards AS, Bernstein EA (1989) Mouse angiotensin I-converting enzyme is a protein composed of two homologous domains. J Biol Chem 264:11945–11951

    PubMed  CAS  Google Scholar 

  • Corvol P, Williams TA, Soubrier F (1995) Peptidyl dipeptidase A: angiotensin I-converting enzyme. Methods Enzymol 248:283–305

    Article  PubMed  CAS  Google Scholar 

  • Cushman DW, Cheung HS (1971) Concentrations of angiotensin-converting enzyme in tissues of the rat. Biochim Biophys Acta 250:261–265

    Article  PubMed  CAS  Google Scholar 

  • Delmas V, van der Hoorn F, Mellstrom B, Jegou B, Sassone-Corsi P (1993) Induction of CREM activator proteins in spermatids: down-stream targets and implications for haploid germ cell differentiation. Mol Endocrinol 7:1502–1514

    Article  PubMed  CAS  Google Scholar 

  • Ehlers MR, Fox EA, Strydom DJ, Riordan JF (1989) Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme. Proc Natl Acad Sci USA 86:7741–7745

    Article  PubMed  CAS  Google Scholar 

  • Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE (1996) Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology and reduced male fertility. Lab Invest 74:953–965

    PubMed  CAS  Google Scholar 

  • Esther CR Jr, Marino EM, Howard TE, Corvol P, Capecchi MR, Bernstein KE (1997a) The critical role of tissue angiotensin converting enzyme (ACE) as revealed by gene targeting in mice. J Clin Invest 99:2375–2385

    Article  PubMed  CAS  Google Scholar 

  • Esther CR Jr, Semeniuk D, Marino EM, Zhou Y, Overbeek PA, Bernstein KE (1997b) Expression of testis angiotensin-converting enzyme is mediated by a cyclic AMP response element Lab Invest 77:483–488

    CAS  Google Scholar 

  • Goldblatt H, Lynch J, Hanzal RF, Summerville WW (1934) Studies on experimental hypertension. I. The production and persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med 59:347–380

    Article  PubMed  CAS  Google Scholar 

  • Howard TE, Shai S-Y, Langford KG, Martin BM, Bernstein KE (1990) Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene. Mol Cell Biol 10:4294–4302

    PubMed  CAS  Google Scholar 

  • Howard TE, Balogh R, Overbeek P, Bernstein KE (1992) Sperm specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91 base pair promoter encoding a CRE-like element. Mol Cell Biol 1 3:18–27

    Google Scholar 

  • Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O (1995) Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 92:2735–2739

    Article  PubMed  CAS  Google Scholar 

  • Kumar RS, Kusari J, Roy SN, Soffer RL, Sen GC (1989) Structure of testicular angiotensin converting enzyme: a segmental mosaic isozyme. J Biol Chem 264:16754–16758

    PubMed  CAS  Google Scholar 

  • Langford KG, Shai S-Y, Howard TE, Kovac MJ, Overbeek PA, Bernstein KE (1991) Transgenic mice demonstrate a testis specific promoter for angiotensin converting enzyme (ACE). J Biol Chem 266:15559–15562

    PubMed  CAS  Google Scholar 

  • Langford KG, Zhou Y, Russell LD, Wilcox JN, Bernstein KE (1993) Regulated expression of testis angiotensin-converting enzyme during spermatogenesis in mice. Biol Reproduct 48:1210–1218

    Article  CAS  Google Scholar 

  • Lattion AL, Soubrier F, Allegrinin J, Hubert C, Corvol P, Alhenc-Gelas F (1989) The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme. FEBS Lett 252:99–104

    Article  PubMed  CAS  Google Scholar 

  • Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T, Hogan BLM, Ichikawa I (1996) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 96:2947–2954

    Article  Google Scholar 

  • Soubrier F, Alhenc-Gelas F, Hubert C, Allegrinin J, John M, Tregar G, Corvol P (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 85:9386–9390

    Article  PubMed  CAS  Google Scholar 

  • Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, Fukamizu A, Murakami K (1994) Angiotensinogen—deficient mice with hypotension. J Biol Chem 269:31334–31337

    PubMed  CAS  Google Scholar 

  • Tatei K, Cai H, Ip YT, Levine M (1995) Race: a Drosophila homologue of the angiotensin converting enzyme. Mech Dev 51:157–168

    Article  PubMed  CAS  Google Scholar 

  • Tigerstedt R, Bergman PG (1898) Niere und Kreislauf. Scand Arch Physiol 7–8:223–271

    Article  Google Scholar 

  • Zhou Y, Delafontaine P, Martin BM, Bernstein KE (1995) Identification of two positive transcriptional elements within the 91-base pair promoter for mouse testis angiotensin converting enzyme (testis ACE). Dev Genet 16:201–209

    Article  PubMed  CAS  Google Scholar 

  • Zhou Y, Overbeek PA, Bernstein KE (1996a) Tissue specific expression of testis angiotensin converting enzyme is not determined by the —32 nonconsensus TATA motif. Biochem Biophys Res Comm 223:48–53

    Article  PubMed  CAS  Google Scholar 

  • Zhou Y, Sun Z, Means AR, Sassone-Corsi P, Bernstein KE (1996b) cAMP-response element modulator is a positive regulator of testis angiotensin converting enzyme transcription. Proc Natl Acad Sci USA 93:12262–12266

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. K. E. Bernstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Bernstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

M. Stefanini C. Boitani M. Galdieri R. Geremia F. Palombi

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bernstein, K.E., Bernstein, E. (1998). The Control of Testis ACE Expression. In: Stefanini, M., Boitani, C., Galdieri, M., Geremia, R., Palombi, F. (eds) Testicular Function: From Gene Expression to Genetic Manipulation. Ernst Schering Research Foundation Workshop, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03671-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-03671-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03673-0

  • Online ISBN: 978-3-662-03671-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation