Abstract
Male gametogenesis constitutes one of the most dramatic examples of cellular differentiation in the body. During spermiogenesis male germ cells change from round to long and streamlined and almost every subcellular organelle is remodeled. In addition, male germ cells undergo three different types of cell division program in the course of spermatogenesis: stem cell divisions, mitotic amplification divisions, and meio-sis. During the specialized cell division of meiosis, regulation of cell cycle progression is drastically altered by the differentiation program. Work in our laboratory seeks to discover the genes and genetic circuitry that drive the dramatic cellular differentiation of spermatogenesis and coordinate it with the meiotic cell cycle program. To facilitate this genetic approach we study spermatogenesis in Drosophila as a model system.
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Fuller, M.T., White-Cooper, H. (1998). Genetic Control of Meiosis and the Onset of Spermiogenesis in Drosophila. In: Stefanini, M., Boitani, C., Galdieri, M., Geremia, R., Palombi, F. (eds) Testicular Function: From Gene Expression to Genetic Manipulation. Ernst Schering Research Foundation Workshop, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03671-6_4
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DOI: https://doi.org/10.1007/978-3-662-03671-6_4
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