Germ cells are unique in that they are the only cell line able to transmit heritable characteristics. The germ cells and certain cells of the early developing embryo are pluripotent and thus are targeted as the only plausible sites to modify the genome to produce heritable transgenesis. Male and female germ cell lines are developmentally very different. The male continues to produce gametes after puberty while the female germ cells arrest in meiosis prior to birth and complete meiosis only at fertilization. Thus any approach to genetically manipulate germ cells must be quite different in the male and female.
KeywordsGerm Cell Sertoli Cell Donor Cell Seminiferous Tubule Mouse Testis
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