Separation of Chiral Molecules

  • K. Hostettmann
  • A. Marston
  • M. Hostettmann


Optically active natural products generally occur in only one enantiomeric form and do not necessitate chiral separations for their isolation. On the other hand, synthetic, semi-synthetic or modified derivatives may require purification to obtain optically pure compounds.


Chiral Selector Chiral Stationary Phase Chiral Separation Pure Enantiomer Chiral Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Beier RC, Norman JO, Reagor JC, Rees MS, Mundy BP (1993) Nat Toxins 1: 286CrossRefGoogle Scholar
  2. Blaschke G, Bröker W, Fraenkel W (1986) Angew Chem 98: 808CrossRefGoogle Scholar
  3. Dechary JM, Pradel P (1971) J Am Oil Chem Soc 48: 563CrossRefGoogle Scholar
  4. Domon B, Hostettmann K, Kovacevic K, Prelog V (1982) J Chromatogr 250: 149CrossRefGoogle Scholar
  5. Erlandsson P, Hansson L, Isaksson R (1986) J Chromatogr 370: 475CrossRefGoogle Scholar
  6. Felix G, Descorps V, Kopaciewicz W, Coryell B (1995) LC-GC Int. 8: 396Google Scholar
  7. Fitos I, Visy J, Magyar A, Katjar J, Simonyi M (1990) Chirality 2: 161CrossRefGoogle Scholar
  8. Francotte E (1994) J Chromatogr 666: 565CrossRefGoogle Scholar
  9. Francotte E, Junker-Buchheit A (1992) J Chromatogr 576: 1CrossRefGoogle Scholar
  10. Günther K, Carle R, Fleischhauer I, Merget S (1993) Fres J Anal Chem 345: 787CrossRefGoogle Scholar
  11. Harada N, Iwabuchi J, Yokota Y, Uda H, Okamoto Y, Yuki H, Kawada Y (1985) J Chem Soc Perkin Trans I 1845CrossRefGoogle Scholar
  12. Hardt I, König WA (1994) J Chromatogr A 666: 611CrossRefGoogle Scholar
  13. Hesse G, Hagel R (1973) Chromatographia 6: 277CrossRefGoogle Scholar
  14. Jacobson S, Felinger A, Guiochon G (1992) Biotechnol Bioeng 40: 1210CrossRefGoogle Scholar
  15. King Ti de Silva LB ((1968) Tetrahedron Lett 3:261Google Scholar
  16. Kramell R, Schneider G, Miersch O (1996) Phytochem Anal 7: 209CrossRefGoogle Scholar
  17. Krause M, Galensa R (1990) J Chromatogr 514: 147CrossRefGoogle Scholar
  18. Krause M, Galensa R (1991) J Chromatogr 588: 41CrossRefGoogle Scholar
  19. Lämmerhofer M, Lindner G (1996) J Chromatogr A 741: 33CrossRefGoogle Scholar
  20. Lindner KR, Mannschreck A (1980) J Chromatogr 193: 308CrossRefGoogle Scholar
  21. Ma Y, Ito Y (1995) Anal Chem 67: 3069CrossRefGoogle Scholar
  22. Ma Y, Ito Y, Foucault A (1995) J Chromatogr 704: 75CrossRefGoogle Scholar
  23. Matlin SA, Zhou R (1984) J High Res Chromatogr 7: 629CrossRefGoogle Scholar
  24. Matlin SA, Belenguer A, Tyson RG, Brookes AN (1987) J High Res Chromatogr 10: 86CrossRefGoogle Scholar
  25. Matlin SA, Grieb SJ, Belenguer AM (1995) J Chem Soc Chem Commun 301Google Scholar
  26. Okamoto Y, Kaida Y, Hayashida H, Hatada K (1990) Chem Lett 909Google Scholar
  27. Oliveros L, Franco Puertolas P, Minguillon C, Camacho-Frias E, Foucault A, Le Goffic F (1994) J Liq Chromatogr 17: 2301CrossRefGoogle Scholar
  28. Osawa K, Yasuda H, Maruyama T, Morita H, Takeya K, Itokawa H (1992) Chem Pharm Bull 40: 2970CrossRefGoogle Scholar
  29. Pirkle WH, Finn JM (1982) J Org Chem 47: 4037CrossRefGoogle Scholar
  30. Pirkle WH, Murray PG (1993) J Chromatogr 641: 11CrossRefGoogle Scholar
  31. Pirkle WH, Tsipouras A, Sowin TJ (1985) J Chromatogr 319: 392CrossRefGoogle Scholar
  32. Prelog V, Stojanac Z, Kovacevic K (1982) Heiv Chim Acta 65: 377CrossRefGoogle Scholar
  33. Rieck A, Billow N, König WA (1995) Phytochemistry 40: 847CrossRefGoogle Scholar
  34. Rosini C, Bertucci C, Pini D, Altemura P, Salvadori P (1985) Tetrahedron Lett 26: 3361CrossRefGoogle Scholar
  35. Salvadori P, Pini D, Rosini C, Bertucci C, Uccello-Barretta G (1992) Chirality 4: 43CrossRefGoogle Scholar
  36. Schlögl K, Widhalm M (1984) Monatsh Chemie 115: 1113CrossRefGoogle Scholar
  37. Shaw CJ, Sanfilippo PJ, McNally JJ, Park SA, Press JB (1993) J Chromatogr 631: 173CrossRefGoogle Scholar
  38. Subramanian G (1994) A practical approach to chiral separations by liquid chromatography. VCH, WeinheimGoogle Scholar
  39. Takeuchi T, Horikawa R, Tanimura T (1984) J Chromatogr 284: 285CrossRefGoogle Scholar
  40. Werner A (1989) Kontakte (Darmstadt) 50Google Scholar
  41. Zsadon B, Décsei L, Szilasi M, Tüdos F (1983) J Chromatogr 270: 127CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • K. Hostettmann
    • 1
  • A. Marston
    • 1
  • M. Hostettmann
    • 1
  1. 1.Institute of Pharmacognosy and PhytochemistryUniversity of LausanneLausanne — DorignySwitzerland

Personalised recommendations