Glutamate in Neurodegenerative Disorders: Phenotype Resulting from Decreased Expression of AMPA Receptor GIuR-B Subunit mRNA in Rats

  • G. Müller
  • U. Endermann
  • I. Bresink
  • L. Turski
Conference paper
Part of the Ernst Schering Research Foundation Symposium Workshop book series (SCHERING FOUND, volume 23)

Abstract

The excitatory neurotransmitter glutamate activates various classes of ionotropic receptors in the mammalian central nervous system. αAmino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and kainate (KA) receptor stimulation triggers Na+ influx into neurons, while N-methyl-D-aspartate (NMDA) receptor stimulation additionally leads to considerable Ca2+ influx (Hollmann and Heinemann 1994). Relative impermeability of the AMPA receptor channel to Ca2+ is regulated by the Q/R locus within the channel pore on the M2 region of the G1uR-B subunit. Expression of either glutamine (Q) or arginine (R) within this locus is controlled by posttranscriptional RNA editing (Sommer et al. 1991). Transgenic mice engineered to synthesize unedited GluR-B subunits express Ca2+permeable AMPA receptors. These mice develop progressive neurodegeneration and spontaneous seizures (Brusa et al. 1995).

Keywords

Permeability Cage Arginine Glutamine NMDA 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • G. Müller
  • U. Endermann
  • I. Bresink
  • L. Turski

There are no affiliations available

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