Cardiovascular Gene Therapy
We are poised on the threshold of a new era; the ability to alter the genetic make up and/or expression of genes in humans. The prospect is a single injection of a gene therapeutic curing familial hypercholesterolemia, correcting severe combined immunodeficiency, removing the death sentence from those with a hereditary colon cancer gene, or growing new blood vessels to relieve chronic myocardial ischemia. The last decade has seen much progress toward reaching these goals, but we are not there yet. We review here the status of cardiovascular gene therapy in the published literature as of February 1998; mindful of the rapidly moving field we are surveying.
KeywordsGene Therapy Gene Transfer Familial Hypercholesterolemia Smooth Muscle Proliferation Fibroblast Growth Factor Family
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