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Ribozymes as Biotherapeutic Tools for the Modulation of Gene Expression

  • Conference paper
Gene Therapy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 27))

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Abstract

The better the expression patterns and interactions of genes have been understood, the more it has become apparent that carcinogenesis is a multistep process of genetic alterations of oncogenes and/or tumor suppressor genes (Foulds 1958; Fearon and Vogelstein 1990). Small molecules interfering with genetic deregulation might become key players in the future search for new anti—cancer drugs. Examples of such molecules include antisense oligonucleotides (Zamecnik and Stephenson 1978; Melton 1985; Stein and Cheng 1993), triplex forming oligonucleotides (Felsenfeld et al. 1957; Morgan and Wells 1968; Curcio et al. 1997), peptide nucleic acids (Demidov et al. 1993), and aptamers (Stull and Szoka 1995); ribozymes as small RNA molecules with intrinsic specific catalytic activity are one of the most promising candidates for future molecular drugs (Irie et al. 1997).

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  1. B. Anderegg
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  2. A. Irie
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  3. K. J. Scanlon
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R. E. Sobol K. J. Scanlon E. Nestaas

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Anderegg, B., Irie, A., Scanlon, K.J. (1998). Ribozymes as Biotherapeutic Tools for the Modulation of Gene Expression. In: Sobol, R.E., Scanlon, K.J., Nestaas, E. (eds) Gene Therapy. Ernst Schering Research Foundation Workshop, vol 27. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03577-1_6

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