Of Proteins, Redox States and Living Things

  • L. Moldovan
  • P. J. Goldschmidt-Clermont
Conference paper
Part of the Centre de Physique des Houches book series (LHWINTER, volume 10)


Proteins are amazing structures. For a long while, we have trusted them to be these inoffensive, carefully crafted, highly organized particles, coded for by individual genes (by all means the culprits), and contributing largely to the harmonious activity of cells and tissues. With the recent discovery that proteins can transmit such obscure diseases as Creutzfeld-Jakob neurodegeneration, capable of twisting the programming of invaded cells, the prion proteins, and by analogy, all proteins, have forever lost our trust.


NADPH Oxidase Actin Filament Actin Cytoskeleton Stress Fiber Chronic Granulomatous Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abate C., Patel L., Rauscher F.J. and Curran T., Science 249 (1990) 1157–1162.ADSCrossRefGoogle Scholar
  2. Abo A., Pick E., Hall A., Totty N., Teahan C.G. and Segal A.W., Nature 353 (1991) 668–670.ADSCrossRefGoogle Scholar
  3. Adamski J., Husen B., Thole H.H., Groeschel-Stewart U. and Jungblut P.W., Biochem. J. 296 (1993) 797–802.Google Scholar
  4. Alberts B., Bray D., Lewis J., Raff M., Roberts K. and Watson J.D., In Molecular Biology of the Cell (Garland Publishing, Inc., 1994).Google Scholar
  5. Aon M.A., Cáceres A. and Cortassa S., J. Cell. Biochem. 60 (1996) 271–278.CrossRefGoogle Scholar
  6. Bagrodia S., Taylor S.J., Creasy C.L. Chernoff J. and Cerione R.A., J. Biol. Chem. 270 (1995) 22731–22737.CrossRefGoogle Scholar
  7. Beckmann R.P., Lovett M. and Welch W.J., J. Cell. Biol. 117 (1992) 1137–1150.CrossRefGoogle Scholar
  8. Bereiter-Hahn J., Stübig C. and Haymann V., Exp. Cell. Res. 218 (1995) 551–560.CrossRefGoogle Scholar
  9. Bokoch G.M., Curr. Opin. Cell. Biol. 6 (1994) 212–218.CrossRefGoogle Scholar
  10. Bokoch G.M. and Prossnitz V., J. Clin. Invest. 89 (1992) 402–408.CrossRefGoogle Scholar
  11. Boguski M.S. and McCormick F., Nature 366 (1993) 643–654.ADSCrossRefGoogle Scholar
  12. Borlongan C.V., Kanning K., Poulos S.G., Freeman T.B., Cahill D.W. and Sanberg P.R., J. Fla. Med. Assoc. 83 (1996) 335–341.Google Scholar
  13. Bretscher A., Ann. Rev. Cell. Biol. 7 (1991) 337–374.CrossRefGoogle Scholar
  14. Buchner J., FASEB J. 10 (1996) 10–19.Google Scholar
  15. Burdon R.H., Free Rad. Biol. Med. 18 (1995) 775–794.CrossRefGoogle Scholar
  16. Boume H.R., Sanders D.A. and McCormick F., Nature 349 (1991) 117–127.ADSCrossRefGoogle Scholar
  17. Byers H. R. and Fujiwara K., J. Cell. Biol. 93 (1982) 804–811.CrossRefGoogle Scholar
  18. Carlier M.F. and Pantaloni D., Semin. Cell. Biol. 5 (1994) 183–191.CrossRefGoogle Scholar
  19. Cassimeris L., Safer D., Nachmias Z.T. and Zigmond S.H., J. Cell. Biol. 119 (1992) 1261–1270.CrossRefGoogle Scholar
  20. Clarke F.M. and Masters C.J., Biochim. Biophys. Acta 381 (1975) 37–46.CrossRefGoogle Scholar
  21. Cooper J.A., Ann. Rev. Physiol. 105 (1991) 585–605.CrossRefGoogle Scholar
  22. Coso O.A., Chiarello M., Yu J.C., et al., Cell. 81 (1995) 1137–1146.CrossRefGoogle Scholar
  23. de Crouy-Chanel A., Kohiyama M. and Richarme G., J. Biol. C’hem. 270 (1995) 22669–22672.CrossRefGoogle Scholar
  24. Crawford L.E, Tucker R.W., Heldman A.W. and Goldschmidt-Clermont P.J., In Actin: Biophysics, Biochemistry, and Cell Biology, edited by J.E. Estes and P.J. Higgins (Plenum Press, 1994) pp. 105–112.Google Scholar
  25. Crawford L.E., Milliken E, Irani K., et al., J. Biol. Chem. 271 (1996) 26863–26867.CrossRefGoogle Scholar
  26. Dagher M.C., Fuchs A., Bourmeyster N., Jouan A. and Vignais P.V., Biochimie 77 (1995) 651–660.CrossRefGoogle Scholar
  27. Davies P.F., Robotewskyj A. and Griem M.L. J Clin. Invest. 93 (1994) 2031–2038.CrossRefGoogle Scholar
  28. Davies K.J., Biochem. Soc. Symp. 61 (1995) 1–31.Google Scholar
  29. Dreher D. and Junod A.F., Eur. J. Cancer. 32A (1996) 30–38.CrossRefGoogle Scholar
  30. Emmendorffer A., Roesler J., Elsner J., Raeder E., Lohmann-Matthes M.L. and Meier B., Eur. J. Haematol. 51 (1993) 223–227.CrossRefGoogle Scholar
  31. Flitter W.D., Brit. Med. Bull. 49 (1993) 545–555.Google Scholar
  32. Friend C.M., Sci. Am. 268 (1993) 74–79CrossRefGoogle Scholar
  33. Gabbiani G., Gabbiani F., Lombardi D. and Schwartz S.M., Proc. Nat. Acad. Sci. USA 80 (1983) 2361–2364.ADSCrossRefGoogle Scholar
  34. Goldschmidt-Clermont P.J., Machesky L.M., Baldassare J.J. and Pollard T.D., Science 247 (1990) 1575–1578.ADSCrossRefGoogle Scholar
  35. Goldschmidt-Clermont P.J. and Janmey P.A., Cell. 66 (1991) 419–421.CrossRefGoogle Scholar
  36. Goldschmidt-Clermont P.J., Furman M.I., Wachsstock D., Safer D., Nachmias V.T. and Pollard T.D., Molec. Biol. Cell. 3 (1992a) 1015–1024.Google Scholar
  37. Goldschmidt-Clermont P.J., Mendelsohn M.E. and Gibbs J.B., Curr. Biol. 2 (1992b) 669–671.CrossRefGoogle Scholar
  38. Goldstone S.D., Fragonas J.C., Jeitner T.M. and Hunt N.H., Biochim. Biophys. Acta 1263 (1995) 114–122.CrossRefGoogle Scholar
  39. Goldstone S.D., Milligan A. and Humt N.H., Biochim. Biophys. Acta 1314 (1996) 175–182.CrossRefGoogle Scholar
  40. Gotlieb A.L., Toxicol. Pathol. 18 (1990) 603–617.Google Scholar
  41. Heldman A.W., Kandzari D.E., Tuckcer R.W., et al., Circ. Res. 78 (1996) 312–321.CrossRefGoogle Scholar
  42. Hancock J.F., Paterson H. and Marshall C.J., Cell. 63 (1990) 133–139.CrossRefGoogle Scholar
  43. Herman B. and Pledger W.J., J. Cell. Biol. 100 (1985) 1031–1040.CrossRefGoogle Scholar
  44. Irani K. and Goldschmidt-Clermont P.J., Biochem. Pharmacol. 55 (1998) 1339–1346.CrossRefGoogle Scholar
  45. Irani K., Xia Y., Zwlier J.L., et al., Science 275 (1997) 1649–1652.CrossRefGoogle Scholar
  46. Janmey P.A., Ann. Rev. Physiol. 56 (1994) 169–191.CrossRefGoogle Scholar
  47. Janmey P.A. and Stossel T.P., J. Biol. Chem. 264 (1989) 4825–4831Google Scholar
  48. Jenner P., Pathol. Biol. 44 (1996) 57–64.Google Scholar
  49. Jockusch B.M., Bubeck P., Giehl K., et al., Ann. Rev. Cell. Dev. Biol. 11 (1995) 379–416.CrossRefGoogle Scholar
  50. Joneson T., McDonough M., Bar-Sagi D. and Van Aelst L., Science 274 (1996) 1374–1376.ADSCrossRefGoogle Scholar
  51. Knaus U.G., Heyworth P.G., Evans T., Curnutte J.T. and Bokoch G.M., Science 254 (1991) 1512–1515.ADSCrossRefGoogle Scholar
  52. Kreis T.E. and Birchmeier W., Cell. 22 (1980) 555–561.CrossRefGoogle Scholar
  53. Kuo H.J., Malencick D.A., Liou R.S. and Anderson S.R., Biochemistry 25 (1986) 1378–1286.CrossRefGoogle Scholar
  54. Larochelle D.A, Vithalani K.K. and De Lozanne A., J. Cell. Biol. 133 (1996) 1321–1329.CrossRefGoogle Scholar
  55. Laufenburger D.A. and Horwitz A.F., Cell. 84 (1996) 359–369.CrossRefGoogle Scholar
  56. Lassing I. and Lindberg K., Nature 314 (1985) 472–474.ADSCrossRefGoogle Scholar
  57. Lee T. and Montell D.J., Develop. Biol. 185 (1997) 25–33.CrossRefGoogle Scholar
  58. Lowy D.R., Johnoson M.R., DeClue J.E., et al., Ciba Found. Symp. 176 (1993) 67–84.Google Scholar
  59. Manser E., Leung T., Salihuddin H., Zhao Z.S. and Lim L., Nature 367 (1994) 40–46.ADSCrossRefGoogle Scholar
  60. Matsudaira P., and Janmey P.A., Cell. 54 (1988) 139–140.CrossRefGoogle Scholar
  61. Meier B., Cross A.R., Hancock J.T., Kaup F.J. and Jones O.T.G., Biochem. J, 275 (1991) 241–245.Google Scholar
  62. Meier B., Jesaitis A.J., Emmendorfer A., Roesler J. and Quinn M.T., Biochem. J. 289 (1993) 481–486.Google Scholar
  63. Minden A., Lin A., Claret F.X., Abo A. and Karin M., Cell. 81 (1995) 1147–1157.CrossRefGoogle Scholar
  64. Mockrin S.C. and Korn E.D., Biochemistry 19 (1980) 5359–5362.CrossRefGoogle Scholar
  65. Negulayev Y.A., Vedernikova E.A. and Maximov A.V., Mol. Biol. Cell. 7 (1996) 1857–1864.Google Scholar
  66. Nobes C.D. and Hall A., Cell. 81 (1995) 53–62.CrossRefGoogle Scholar
  67. Nohl H., Br. Med. Bull. 49 (1993) 653–667Google Scholar
  68. Norman J.C., Price L.S., Ridley A.J., Hall A. and Koffer A., J. Cell. Biol. 126 (1994) 1005–1015.CrossRefGoogle Scholar
  69. Nusrat A., Giry M., Turner J.R., et al., Proc. Nat. Acad. Sci. USA 92 (1995) 10629–10633.ADSCrossRefGoogle Scholar
  70. Peppelenbosch M.P., Qiu R.G., de Vries-Smits A.M.M., et al., Cell. 81 (1995) 849–856.CrossRefGoogle Scholar
  71. Poglazov B.F. and Livanova N.B., Adv. Enzyme Regul. 25 (1986) 297–305.CrossRefGoogle Scholar
  72. Pollard T.D., In Signal Transduction in Cytoplasmic Organization and Cell Motility (A.R. Liss, Inc., 1988) pp. 263–269.Google Scholar
  73. Pollard T.D. and Cooper J.A., Biochemistry 23 (1984) 6631–6641.CrossRefGoogle Scholar
  74. Pollard T. and Cooper J.A., Ann. Rev. Biochem. 55 (1986) 987–1035.CrossRefGoogle Scholar
  75. Polyak K., Xia Y., Zwier J.L., Kinzler K. W. and Vogelstein B., Nature 389 (1997) 300–305.ADSCrossRefGoogle Scholar
  76. Pratt W.B., Ann. Rev. Pharmacol. Toxicol. 37 (1997) 297–326.CrossRefGoogle Scholar
  77. Prinsze C., Dubbelman T.M. and Van Steveninck J., Biochim. Biophys. Acta 1038 (1990) 152–157.CrossRefGoogle Scholar
  78. Ridley A.J. and Hall A., Cell. 70 (1992) 389–399.CrossRefGoogle Scholar
  79. Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D. and Hall A., Cell. 70 (1992) 401–410.CrossRefGoogle Scholar
  80. Robinson J.M. and Badwey J.A., Histochemistty 103 (1995) 163–180.CrossRefGoogle Scholar
  81. Schliwa M., Nakamura T., Porter K.R. and Euteneuer U., J. Cell. Biol. 99 (1984) 1045–1059.CrossRefGoogle Scholar
  82. Sen C.K. and Packer L., FASEB J. 10 (1996) 709–720.Google Scholar
  83. Sundaresan M., Yu Z.X., Ferrans V.J., Irani K. and Finkel T., Science 270 (1995) 296–299.ADSCrossRefGoogle Scholar
  84. Suzuki Y.J., Forman H.J. and Sevanian A., Free Rad. Biol. Med. 22 (1997) 269–285.CrossRefGoogle Scholar
  85. Tamkun J.W., DeSimone D.W., Fonda D., Patel R.S., Buck C., Horwitz A.F. and Hynes R.O., Cell. 46 (1986) 271–282.CrossRefGoogle Scholar
  86. Theriot J.A. and Mitchison T.J., J. Cell. Biol. 119 (1992) 367–377.CrossRefGoogle Scholar
  87. Thrasher A.J., Keep N.H., Wientjes F. and Segal A.W., Biochim. Biophys. Acta 1227 (1994) 1–24.CrossRefGoogle Scholar
  88. Toyokuni S., Free Radic. Biol. Med. 20 (1996) 553–566.CrossRefGoogle Scholar
  89. Van Aelst L., Joneson T. and Bar-Sagi D., EMBO J. 15 (1996) 3778–3786.Google Scholar
  90. Walsh TP., Clarke F.M. and Masters C.J., Biochem. J. 165 (1977) 165–167.Google Scholar
  91. Westwick J.K., Lambert Q.T., Clark G.J., et al., Molec. Cell. Biol. 17 (1997) 1324–1335.Google Scholar
  92. Wong A.J., Pollard T.D. and Herman I.M., Science 219 (1982) 867–869.ADSCrossRefGoogle Scholar
  93. Yin H.L. and Stossel T.P., Nature 281 (1979) 583–586.ADSCrossRefGoogle Scholar
  94. Yun H.Y., Dawson V.L. and Dawson T.M., Mol. Psychiatry 2 (1997) 300–310.CrossRefGoogle Scholar
  95. Zweier J.L., Broderick R., Kuppusamy P., Thompson-Gorman S. and Lutty G.A., J. Biol. Chem. 269 (1994) 24156–24162.Google Scholar

Copyright information

© Springer-Verlag France 1998

Authors and Affiliations

  • L. Moldovan
    • 1
  • P. J. Goldschmidt-Clermont
    • 1
  1. 1.The Heart and Lung Institute at the Ohio State University 420 W12th Avenue ColumbusUSA

Personalised recommendations