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The Immunological Basis for the Development of Tumor Cell- and Peptide-Based Vaccines for Treatment of Patients with Renal Cell Carcinoma

  • D. J. Schendel
  • E. Nößner
  • B. Maget
  • S. Kressenstein
  • K. Pantel
  • R. Oberneder
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 20)

Abstract

The failure of metastatic renal cell carcinoma (RCC) to respond to irradiation, chemotherapy or hormone therapy has left immunotherapy as the most hopeful form of treatment to date. Systemic cytokine therapy of RCC using recombinant interleukin-2 (rIL-2) alone or in combination with recombinant interferon-α (rIFN-α) has led to objective response rates of 20%–30% (Belldegrun et al. 1991; Rosenberg 1992). Nevertheless, few complete and long-lasting remissions have been achieved and severe toxic side effects limit their broad application. These obstacles have spurred efforts to develop alternative strategies to modulate immune responses of RCC patients. In particular, new approaches are sought for treatment of patients with minimal residual disease. In the forefront are attempts to develop genetically engineered tumor cell vaccines and peptide vaccines that will induce tumor-specific immune responses in vivo.

Keywords

Renal Cell Carcinoma Major Histocompatibility Complex Minimal Residual Disease Renal Cell Carcinoma Patient Peptide Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • D. J. Schendel
  • E. Nößner
  • B. Maget
  • S. Kressenstein
  • K. Pantel
  • R. Oberneder

There are no affiliations available

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