Abstract
Osteoclastic destruction of bone is a cyclic activity with several separate phases (Fig. 1). Nitric oxide (NO) has a major influence on several of these: (1) it inhibits preosteoclast proliferation; (2) a “puff” of NO, triggered by calcium-stimulated constitutive nitric oxide synthase (cNOS) facilitates cell detachment and subsequent movement; (3) the radical is probably involved in the final apoptotic phase of the cycle; (4) the gas radical plays an important role in osteoclast detachment and motility (Fig. 2) and is essential for osteoclast activity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ake Y, Saegusa Y, Matsubara T, Mizuno K (1994) Cultured osteoblast synthesize nitric oxide in response to cytokines and lipopolysaccharide. Kobe J Med Sci 40: 125–137
Brandi ML, Hukkanen M, Umeda T, Moradi-Bidhendi N, Bianchi S, Gross S, Polak JM, Maclntyre I (1995) Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc Natl Acad Sci USA 92: 2954–2958
Damoulis PD, Hauschka PV (1994) Cytokines induce nitric oxide production in mouse osteoblasts. Biochem Biophys Res Commun 201: 924–931
Fiorelli G, Gori F, Frediani U, Franceschelli F, Tanini A, Tosti-Guerra C, Benvenuti S, Gennari L, Becherini L, Brandi ML (1996) Membrane binding sites and nongenomic effects of estrogen in cultured human pre-osteoclastic cells. J Steroid Biochem Mol Biol: 59: 223–240
Fox SW, Chambers TJ, Chow JWM (1995) Nitric oxide is an early mediator of the induction of bone formation by mechanical stimulation. J Bone Miner Res 10 [Suppl 1]: S204 (Abstract no S212, 17th annual meeting of the American Society for Bone and Mineral Research, Baltimore, Maryland, 9–13 Sept 1995)
Hukkanen M, Hughes FJ, Buttery LDK, Gross SS, Evans TJ, Seddon S, Riveros-Moreno V, MacIntyre I, Polak JM (1995) Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology 136: 5445–5453
Jones DB, Tenbosch J (1995) Mechanotransduction in osteoblasts. Acta Anat 152: 297–298 (Abstract no 143, 10th European Anatomical Congress, Florence, 17–21 Sept 1995)
Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP, Settle, SL, Currie MG, Nickols GA (1994) Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA 91: 3569–3573
Lizasoain I, Weiner CP, Knowles RG, Moncada S (1994) Oestrogen-dependent increases in nitric oxide synthase activity during development in foetal and neonatal guinea-pig brain. In: Moncada S, Feelisch M, Busse R, Higgs EA (eds) Physiological and clinical aspects. Proceedings of the 3rd international meeting on the biology of nitric oxide, Cologne, Germany. Portland, London, pp 288–291 (The biology of nitric oxide, vol 3)
Lowik CWGM, Nibbering PH, van de Ruit M, Papapoulos SE (1994) Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 93: 1465–1472
Maclntyre I, Zaidi M, Towhidul Alam ASM, Datta HK, Moonga BS, Lidbury PS, Hecker M, Vane JR (1991) Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci USA 88: 2936–2940
Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE (1995) Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? FASEB J 9: 1614–1622
Ralston SH, Todd D, Helfrich M, Benjamin N, Grabowski PS (1994) Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135: 330–336
Rawlinson SCF, Pitsillides AA, Lanyon LE (1995) Mechanodependent signalling pathways in osteocytes and osteoblasts. J Bone Miner Res 10 [Suppl 1]: S342 (Abstract no M357, 17th annual meeting of the American Society for Bone and Mineral Research, Baltimore, Maryland, 9–13 Sept 1995)
Riancho JA, Salas E, Zarrabeitia MT, Olmos JM, Amado JA, Fernandez-Luna JL, Gonzalez-Macias J (1995a) Expression and functional role of nitric oxide synthase in osteoblast-like cells. J Bone Miner Res 10: 439–446
Riancho JA, Zarrabetia MT, Fernandez-Luna JL, Gonzalez-Macias J (1995b) Mechanisms controlling nitric oxide synthesis in osteoblasts. Mol Cell Endocrinol 107: 87–92
Turner CH, Owan I, Takano Y, Madalli S, Murrell GAC (1995) Nitric oxide plays a role in bone mechanotransduction. J Bone Miner Res 10 [Suppl 1]: S235 (Abstract no S337, 17th annual meeting of the American Society for Bone and Mineral Research, Baltimore, Maryland, 9–13 Sept 1995)
Van Epps-Fung C, Williams JP, Cornwell TL, Lincoln TM, McDonald JM, Radding W, Blair HC (1994) Regulation of osteoclastic acid secretion by cGMP-dependent protein kinase. Biochem Biophys Res Commun 204: 565–571
Wimalawansa SJ, De Marco G, Gangula P, Yallampalli C (1996) Nitric oxide donor alleviates ovariectomy-induced bone loss. Bone 18: 301–304
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Moradi-Bidhendi, N., Mancini, L., Maclntyre, I. (1997). Nitric Oxide and the Skeleton. In: Lancaster, J.R., Parkinson, J.F. (eds) Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones. Ernst Schering Research Foundation Workshop, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03503-0_8
Download citation
DOI: https://doi.org/10.1007/978-3-662-03503-0_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-03505-4
Online ISBN: 978-3-662-03503-0
eBook Packages: Springer Book Archive