Nitric Oxide in Arthritis: It’s Probably There But What’s It Doing?
Arthritis is a disease of diarthrodial joints. Although some forms of arthritis involve extraarticular tissues, the most prominent pathological lesions occur within the joints and all forms of arthritis produce articular inflammation or cartilage destruction or both. Patients with osteoarthritis (OA), for example, suffer considerable loss of cartilage with only low levels of inflammation, whereas the joints of patients with systemic lupus erythematosus (SLE; lupus) do not lose cartilage, despite being highly inflamed. Extensive cartilage loss and high levels of inflammation occur together in the joints of patients with rheumatoid arthritis (RA). In considering the possible roles of nitric oxide (NO) in arthritis, it is thus necessary to determine how NO influences both inflammation and cartilage erosion within joints. As these are distinct pathophysiological processes (Evans 1995a) they could respond differently to NO.
KeywordsNitrite Osteoarthritis Prostaglandin Glucocorticoid Alginate
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