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Endothelial Cells, Estrogen and Angiogenesis

  • H. W. Schnaper
  • K. A. McGowan
  • S. C. Hubchak
  • M. C. Cid
  • H. K. Kleinman
  • S. Kim-Schulze
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 21)

Abstract

Increasing clinical evidence supports a role for estrogen in modulating vascular cell function. Premenopausal women enjoy relative protection from heart attacks and strokes compared with men. After menopause, the incidence of atherosclerotic cardiovascular disease rapidly approximates that of men (Stampfer et al. 1990). Moreover, several studies have indicated that postmenopausal estrogen replacement therapy may decrease the incidence of subsequent cardiovascular events in women (Grady et al. 1992; Psaty et al. 1994; Folsom et al. 1995; Writing Group for the PEPI Trial 1995). A role for estrogen in vascular biology is further suggested by the observation that women have higher rates of certain inflammatory diseases than do men, including several diseases that are associated with local angiogenesis (Beeson 1994). Third, spider angiomas are common occurrences in pregnant women or in men with chronic liver disease. After pregnancy ends, or when the cause of the high-estrogen status of the men with hepatic dysfunction is addressed, the angiomas usually resolve (Pirovino et al. 1988). Together, these findings support the concept that estrogen has clinically significant effects on endothelial cell activity related to both atherosclerosis and angiogenesis.

Keywords

Estrogen Receptor Human Umbilical Vein Endothelial Cell Endothelial Cell Activity Estrogen Response Element Endothelial Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • H. W. Schnaper
  • K. A. McGowan
  • S. C. Hubchak
  • M. C. Cid
  • H. K. Kleinman
  • S. Kim-Schulze

There are no affiliations available

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