Skip to main content
SpringerLink
Log in

Estrogen, Nitric Oxide, and Primate Atherosclerosis

  • Conference paper
Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 21))

  • 160 Accesses

Abstract

Coronary heart disease (CHD) is the leading cause of death among postmenopausal women in Western societies. It is generally accepted that CHD risk is reduced by about 50% in postmenopausal women who take conjugated equine estrogens (CEE) daily (Bush 1990; Stampfer and Colditz 1991). Observational studies of postmenopausal women undergoing angiography for chest pain have shown that coronary artery occlusions are fewer among estrogen users than nonusers (Sullivan 1993; Gruchow et al. 1988; Hong et al. 1992). These data suggest that estrogen may reduce CHD risk by affecting atherogenesis. Recent studies have explored the mechanism(s) by which estrogen reduces CHD risk and inhibits atherogenesis. One of the main areas of attention is the potential role of nitric oxide (NO) as an important mediator of estrogen’s effects on coronary artery disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams MR, Kaplan JR, Manuck SB, Koritnik DR, Parks JS, Wolfe MS, Clarkson TB (1990) Inhibition of coronary artery atherosclerosis by 17 beta-estradiol in ovariectomized monkeys: lack of an effect of added progesterone. Arteriosclerosis 10: 1051–1057

    Article  PubMed  CAS  Google Scholar 

  • Adams MR, Register TC, Golden DL, Wagner JD, Williams JK (1997) Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis. Arterioscler Thromb Vasc Biol 17: 217–221

    Article  PubMed  CAS  Google Scholar 

  • Bush TL (1990) Noncontraceptive estrogen use and risk of cardiovascular disease: an overview and critique of the literature. In: Korenman SG (ed) The menopause: biological and clinical consequences of ovarian failure: evolution and management. Serono Symposia, Norwell, MA, pp 211–224

    Google Scholar 

  • Cayatte AJ, Palacino JJ, Horten K, Cohen RA (1994) Chronic inhibition of nitric oxide production accelerates ncointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 14: 753–759

    Article  PubMed  CAS  Google Scholar 

  • Chang W-C, Nakao J, Orimo H, Murota S-L (1980) Stimulation of prostaglandin cyclooxygenase and prostacyclin synthetase activities by estradiol in rat aortic smooth muscle cells. Biochim Biophys Acta 620: 472–482

    Article  PubMed  CAS  Google Scholar 

  • Clarkson TB, Anthony MS, Klein KP (1996) Hormone replacement therapy and coronary artery atherosclerosis: the monkey model. Br J Obstet Gynaecol 103 [Suppl 131: 53–58

    Google Scholar 

  • Conrad KP, Joffe GM, Kruszyna H, Kruszyna R, Rochelle LG, Smith RP, Chavez JE, Mosher MD (1993) Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J 7: 566–571

    CAS  Google Scholar 

  • Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME (1992) Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 90: 1168–1172

    Article  PubMed  CAS  Google Scholar 

  • Farhat MY, Vargas R, Dingaan B, Ramwell PW (1992) In vitro effect of oestradiol on thymidine uptake in pulmonary vascular smooth muscle cell: role of the endothelium. Br J Pharmacol 107: 679–683

    Article  PubMed  CAS  Google Scholar 

  • Fischer-Dzoga K, Wissler R, Vesselinovitch D (1983) The effect of estradiol on the proliferation of rabbit aortic medial tissue cells induced by hyperlipemic serum. Exp Mol Pathol 39: 355–363

    Article  PubMed  CAS  Google Scholar 

  • Furchgott RF, Zawadski JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373–376

    Article  PubMed  CAS  Google Scholar 

  • Garg UC, Hassid A (1989) Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83: 1774–1777

    Article  PubMed  CAS  Google Scholar 

  • Gisclard V, Flavahan NA, Vanhoutte PM (1987) Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17 beta-estradiol. J Pharmacol Exp Ther 240: 466–470

    PubMed  CAS  Google Scholar 

  • Gisclard V, Miller VM, Vanhoutte PM (1988) Effect of 17 beta-estradiol on endothelium-dependent responses in rabbits. J Pharmacol Exp Ther 244: 19–22

    PubMed  CAS  Google Scholar 

  • Gruchow HW, Anderson AJ, Barboriak J, Sobocinski VA (1988) Postmenopausal use of estrogen and occlusion of coronary arteries. Am Heart J 115: 954–963

    Article  PubMed  CAS  Google Scholar 

  • Harder DR, Coulson PB (1979) Estrogen receptors and effects of estrogen on membrane electrical properties of coronary vascular smooth muscle. J Cell Physiol 100: 375–382

    Article  PubMed  CAS  Google Scholar 

  • Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G (1992) Basal release of nitric oxide from aortic rings is greater in female rabbits than male rabbits: Implications for atherosclerosis. Proc Nati Acad Sci USA 89: 11259–11263

    Google Scholar 

  • Herrington DM, Braden GA, Downes TR, Williams JK (1994) Estrogen modulates coronary vasomotor responses in postmenopausal women with early atherosclerosis. Am J Cardiol 73: 951–952

    Article  PubMed  CAS  Google Scholar 

  • Hill CH, Pullman EP, Starcher B, Shih JCH (1995) Dietary nitroprusside alleviates atherosclerosis in hypercholesterolemic Japanese quail ( Coturnix japonica ). Comp Biochem Physiol 112A: 151–154

    Google Scholar 

  • Hong MK, Romm PA, Reagan K, Green CE, Rackley CE (1992) Effects of estrogen replacement therapy on serum lipid values and angiographically defined coronary artery disease in postmenopausal women. Am J Cardiol 69: 176–178

    Article  PubMed  CAS  Google Scholar 

  • Jiang C, Sarrel PM, Lindsay DC, Poole-Wilson PA, Collins P (1991) Endothelium-independent relaxation of rabbit coronary artery by 17-beta estradiol. Br J Pharmacol 104: 1033–1037

    Article  PubMed  CAS  Google Scholar 

  • Jiang C, Sarrel PM, Poole-Wilson PA, Collins P (1992) Acute effect of 17 beta-estradiol on rabbit coronary artery contractile responses to endothelin1. Am J Physiol 263: H271 — H275

    PubMed  CAS  Google Scholar 

  • Johnson G, Tsao PS, Malloy D, Lefer AM (1990) Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion. J Pharmacol Exp Ther 252: 35–41

    PubMed  CAS  Google Scholar 

  • Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88: 4651–4655

    Article  PubMed  CAS  Google Scholar 

  • Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P (1986) Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 315: 1046–1051

    Article  PubMed  CAS  Google Scholar 

  • MacKenzie JN (1884) Irritation of the sexual apparatus. Am J Med Sci 87: 360–365

    Article  Google Scholar 

  • Mendelsohn ME, Karas RH (1994) Estrogen and the blood vessel wall. Curr Opin Cardiol 9: 619–626

    Article  PubMed  CAS  Google Scholar 

  • Miller VM, Gisclard V, Vanhoutte PM (1988) Modulation of endothelium-dependent and vascular smooth muscle responses by oestrogens. Phlebology 3 [Suppl 11: 63–69

    Google Scholar 

  • Naruse K, Shimizu K, Muramatsu M, Toki Y, Miyazaki Y, Okumura K, Hashimoto H, Ito T (1994) Long-term inhibition of NO synthesis promotes atherosclerosis in hypercholesterolemic rabbit thoracic aorta. Arterioscler Thromb 14: 746–752

    Article  PubMed  CAS  Google Scholar 

  • Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biologic activity of endothelium-derived relaxing factor. Nature 327: 524–526

    Article  PubMed  CAS  Google Scholar 

  • Radamski MW, Palmer RMJ, Moncada S (1990) An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87: 5193–5197

    Article  Google Scholar 

  • Reis SE, Gloth ST, Blumenthal RS, Resar JR, Zacur HA, Gerstenblith G, Brinker JA (1994) Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 89: 52–60

    Article  PubMed  CAS  Google Scholar 

  • Reynolds SRM, Foster FI (1940) Peripheral vascular action of estrogen observed in the ear of the rabbit. J Pharmacol Exp Ther 68: 173–177

    CAS  Google Scholar 

  • Silva de Sa MF, Meirelles RS (1977) Vasodilation effect of estrogen on the human umbilical artery. Gynecol Invest 8: 307–313

    Article  Google Scholar 

  • Stamler J, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J (1989) N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res 65: 789–795

    Article  PubMed  CAS  Google Scholar 

  • Stampfer MJ, Colditz GA (1991) Estrogen replacement and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prey Med 20: 47–63

    Article  CAS  Google Scholar 

  • Sullivan JM (1993) Hormone replacement in the secondary prevention of cardiovascular disease. In: Wenger NK, Speroff L, Packard B (eds) Cardiovascular health and disease in women. Proceedings of an NHLBI conference. LeJacq Communications, Greenwich, CT, pp 189–194

    Google Scholar 

  • Ueland K, Parer JT (1966) Effects of estrogens on the cardiovascular system of the ewe. Am J Obstet Gynecol 96: 400–406

    PubMed  CAS  Google Scholar 

  • Vargas R, Wroblewska B, Rego A, Hatch J, Ramwell PW (1993) Oestradiol inhibits smooth muscle cell proliferation of pig coronary artery. Br J Pharmacol 109: 612–617

    Article  PubMed  CAS  Google Scholar 

  • Wagner JD, Clarkson TB, St Clair RW, Schwenke DC, Shively CA, Adams MR (1991) Estrogen and progesterone replacement therapy reduces LDL accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys. J Clin Invest 88: 1995–2002

    Article  PubMed  CAS  Google Scholar 

  • Weiner CP, Lizasoian L, Baylis SA, Knowles RG, Charles IG, Moncada S (1994) Induction of calcium-dependent nitric oxide synthesis by sex hormones. Proc Natl Acad Sci USA 91: 5212–5216

    Article  PubMed  CAS  Google Scholar 

  • Williams JK, Adams MR, Klopfenstein HS (1990) Estrogen modulates re- sponses of atherosclerotic coronary arteries. Circulation 81: 1680–1687

    Article  PubMed  CAS  Google Scholar 

  • Williams JK, Adams MR, Herrington DM, Clarkson TB (1992) Short-term administration of estrogen and vascular responses of atherosclerotic coronary arteries. J Am Coll Cardiol 20: 452–457

    Article  PubMed  CAS  Google Scholar 

  • Zhang R, Ram JL, Standley PR, Sowers JR (1994) 17 beta-estradiol attenuates voltage-dependent Ca currents in A7r5 vascular smooth muscle line. Am J Physiol 266: C975 — C980

    Google Scholar 

Download references

Authors
  1. J. K. Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. R. Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. B. Clarkson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology and Medicine, LSU Medical Center, 1901 Pardido Street, 70112, New Orleans, LA, USA

    Jack R. Lancaster Jr.

  2. Department of Immunology, Berlex Biosciences, Inc., 15049 San Pablo Ave., Richmond, CA, USA

    John F. Parkinson

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Williams, J.K., Adams, M.R., Clarkson, T.B. (1997). Estrogen, Nitric Oxide, and Primate Atherosclerosis. In: Lancaster, J.R., Parkinson, J.F. (eds) Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones. Ernst Schering Research Foundation Workshop, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03503-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-03503-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03505-4

  • Online ISBN: 978-3-662-03503-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation