Multifunctional Growth Factors in Tumor Progression

  • F. Radvanyi
  • S. Bellusci
  • B. Boyer
  • J. Jouanneau
  • P. Savagner
  • A. M. Vallés
  • J. P. Thiery
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 19)


Our goal is to analyze the role of multifunctional growth factors in epithelial plasticity and, specifically, to study the contribution of these factors to the loss of cohesion among tumor cells leading to the acquisition of motile, invasive, and metastatic behavior.


Hepatocyte Growth Factor Community Effect Cell Scattering Mammary Epithelial Cell Line Acidic Fibroblast Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bellusci S., Moens G, Baudino G, Comoglio P, Nakamura T, Thiery JP, Jouanneau J (1994a) Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene 9:1091–1099PubMedGoogle Scholar
  2. Bellusci S, Moens G, Thiery JP, Jouanneau J (1994b) A scatter factor like factor is produced by a metastatic variant of a rat bladder carcinoma cell line. J Cell Sci 107:1277–1287PubMedGoogle Scholar
  3. Bellusci S, Moens G, Delouvee A, Thiery JP, Jouanneau J (1994–1995) SFL production by carcinoma cells induces the aggressive properties of nonproducing cells in vivo via a community effect. Invas Met 14:319–328Google Scholar
  4. Boyer B, Thiery JP (1993) Cyclic AMP distinguishes between two functions of acidic FGF in a rat bladder carcinoma cell line. J Cell Biol 120:767–776PubMedCrossRefGoogle Scholar
  5. Boyer B, Tucker GC, Vallés AM, Gavrilovic J, Thiery JP (1989a) Reversible transition towards a fibroblastic phenotype in a rat carcinoma cell line. Int J Cancer 4:69–75CrossRefGoogle Scholar
  6. Boyer B, Tucker GC, Vallés AM, Franke WW, Thiery JP (1989b) Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells. J Cell Biol 109:1495–1509PubMedCrossRefGoogle Scholar
  7. Gavrilovic J, Moens G, Thiery JP, Jouanneau J (1990) Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line. Cell Regul 1:1003–1014PubMedGoogle Scholar
  8. Jouanneau J, Gavrilovic J, Caruelle D, Jaye M, Moens G, Caruelle JP, Thiery JP (1991) Secreted or nonsecreted forms of acidic fibroblast growth factor produced by transfected epithelial cells influence cell morphology, motility, and invasive potential. Proc Natl Acad Sci USA 88:2893–2897PubMedCrossRefGoogle Scholar
  9. Jouanneau J, Moens G, Bourgeois Y, Poupon MF, Thiery JP (1994) A minority of carcinoma cells producing acidic fibroblast growth factor induces a community effect for tumor progression. Proc Natl Acad Sci USA 91:286–290PubMedCrossRefGoogle Scholar
  10. Matthay MA, Thiery JP, Lafont F, Stampfer F, Boyer B (1993) Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. J Cell Sci 106:869–878PubMedGoogle Scholar
  11. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A, Tashiro K, Shimizu S (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342:440–443PubMedCrossRefGoogle Scholar
  12. Rodier JM, Vallés AM, Denoyelle M, Thiery JP, Boyer B (1995) pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line. J Cell Biol 131:761–773PubMedCrossRefGoogle Scholar
  13. Savagner P, Vallés AM, Jouanneau J, Yamada KM, Thiery JP (1994) Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. Mol Biol Cell 5:851–862PubMedGoogle Scholar
  14. Tchao R (1982) Novel forms of epithelial cell motility on collagen and on glass surfaces. Cell Motility 4:333–341CrossRefGoogle Scholar
  15. Toyoshima K, Ito N, Hiasa Y, Kamamoto Y, Makiura S (1971) Tissue culture of urinary bladder tumor induced in a rat by N-butyl-N-(4-hydroxybutyl)nitrosamine: establishment of cell line, Nara bladder tumor II. J Natl Cancer Inst 47:979–985PubMedGoogle Scholar
  16. Tucker GC, Boyer B, Gavrilovic J, Emonard H, Thiery JP (1990) Collagenmediated dispersion of NBT- II rat bladder carcinoma cells. Cancer Res 50:129–137PubMedGoogle Scholar
  17. Tucker GC, Boyer B, Vallés AM, Thiery JP (1991a) Combined effects of extracellular matrix and growth factors on NBT- II rat bladder carcinoma cell dispersion. J Cell Sci 100:371–380PubMedGoogle Scholar
  18. Tucker GC, Delouvee A, Jouanneau J, Gavrilovic J, Moens G, Vallés AM, Thiery JP (1991b) Amplification of invasiveness in organotypic cultures after NBT- II rat bladder carcinoma stimulation with in vitro scattering factors. Invasion Metastasis 11:297–309PubMedGoogle Scholar
  19. Vallés AM, Boyer B, Badet J, Tucker GC, Barritault D, Thiery JP (1990a) Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line. Proc Natl Acad Sci USA 87:1124–1128PubMedCrossRefGoogle Scholar
  20. Vallés AM, Tucker GC, Thiery JP, Boyer B (1990b) Alternative patterns of mitogenesis and cell scattering induced by acidic FGF as a function of cell density in a rat bladder carcinoma cell line. Cell Regul 1:975–988PubMedGoogle Scholar
  21. Warren SL, Handel LM, Nelson WJ (1988) Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect. Mol Cell Biol 8:632–646PubMedGoogle Scholar
  22. Weidner KM, Behrens J, Vandekerckhove J, Birchmeier W (1990) Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol 111:2097–2108PubMedCrossRefGoogle Scholar
  23. Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Rieder H, Fonatsch C, Tsubouchi H, Hishida T, Daikuhara Y et al. (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA 88:7001–7005PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • F. Radvanyi
  • S. Bellusci
  • B. Boyer
  • J. Jouanneau
  • P. Savagner
  • A. M. Vallés
  • J. P. Thiery

There are no affiliations available

Personalised recommendations