Human Genetics pp 361-383 | Cite as

Gene Action: Developmental Genetics

  • Friedrich Vogel
  • Arno G. Motulsky

Abstract

Biochemical and molecular genetics has taught us much about the structure of genes and about the genetic control of enzymes and functional proteins. The lessons regarding the genetic basis of embryonic development, however, have been much less satisfactory. The genetics of development is only beginning to be charted on the map of our knowledge of molecular genetic mechanisms, but studies with methods from molecular genetics are now starting to elucidate this field. As in other fields of molecular biology, developmental genetics often uses experimental organisms other than humans because human experimentation is subject to obvious limitations. A textbook of human genetics cannot review the whole field. A broad outline is sketched below, indicating where observations on humans may contribute some additional information. Developmental genetics is historically based on classical developmental mechanics (Entwicklungsmechanik) and developmental physiology, which flourished in the first decades of the twentieth century, based on the work of Roux, Driesch, Spemann, Kühn, Waddington, and Hadorn.

Keywords

Codon Cortisol Progesterone Estradiol Aldosterone 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Friedrich Vogel
    • 1
  • Arno G. Motulsky
    • 2
  1. 1.Institut für Humangenetik und AnthropologieHeidelbergGermany
  2. 2.Division of Medical Genetics, School of MedicineUniversity of WashingtonSeattleUSA

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