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History of Human Genetics

  • Friedrich Vogel
  • Arno G. Motulsky

Abstract

The history of human genetics is particularly interesting since, unlike in many other natural sciences, concepts of human genetics have often influenced social and political events. At the same time, the development of human genetics as a science has been influenced by various political forces. Human genetics because of its concern with the causes of human variability has found it difficult to either remain a pure science or one of strictly medical application. Current concerns regarding the heritability of IQ and the existence of inherited patterns of behavior again have brought the field into public view. A consideration of the history of human genetics with some attention to the interaction of the field with societal forces is therefore of interest. We will concentrate our attention on historical events of particular interest for human genetics and refer to landmarks in general genetics only insofar as they are essential for the understanding of the evolution of human genetics.

Keywords

Genetic Counseling Down Syndrome Sickle Cell Anemia Inborn Error Medical Genetic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Allen GE (1975) Genetics, eugenics and class struggle. Genetics 79: 29–45PubMedGoogle Scholar
  2. 2.
    Baltzer F (1962) Theodor Boveri - Leben und Werk. Wissenschaftliche Verlagsgesellschaft, StuttgartGoogle Scholar
  3. 3.
    Barthelmess A (1952) Vererbungswissenschaft. Alber, FreiburgGoogle Scholar
  4. 4.
    Bearn AG (1993) Archibald Garrod and the individuality of man. Clarendon, OxfordGoogle Scholar
  5. 5.
    Becker PE (1988) Zur Geschichte der Rassenhygiene. Thieme, Stuttgart (Wege ins Dritte Reich, vol 1 )Google Scholar
  6. 6.
    Becker PE (1990) Sozialdarwinismus, Rassismus, Antisemitismus und völkischer Gedanke. Thieme, Stuttgart (Wege ins Dritte Reich, vol 2 )Google Scholar
  7. 7.
    Bernstein F (1924) Ergebnisse einer biostatistischen zusammenfassenden Betrachtung über die erblichen Blutstrukturen des Menschen. Klin Wochenschr 3: 1495–1497CrossRefGoogle Scholar
  8. 8.
    Brock DJH (1977) Biochemical and cytological methods in the diagnosis of neural tube defects. Prog Med Genet 2: 1–40PubMedGoogle Scholar
  9. 9.
    Capelle W (1953) Die Vorsokratiker. Kröner, StuttgartGoogle Scholar
  10. 10.
    Committee for the Study of Inborn Errors of Metabolism, Assembly of Life Sciences NRC (1975) Genetic screening. Programs, principles, and research. National Academy of Sciences, WashingtonGoogle Scholar
  11. 11.
    Cremer T (1986) Von der Zellenlehre zur Chromosomentheorie. Springer, Berlin Heidelberg New YorkGoogle Scholar
  12. 12.
    Dunn LC (1962) Cross currents in the history of human genetics. Am J Hum Genet 14: 1–13PubMedGoogle Scholar
  13. 13.
    Ephrussi B, Weiss MC (1965) Interspecific hybridization of somatic cells. Proc Natl Acad Sci USA 53: 1040PubMedCrossRefGoogle Scholar
  14. 14.
    Falk R (1984) The gene in search of an identity. Hum Genet 68: 195–204PubMedCrossRefGoogle Scholar
  15. 15.
    Galton F (1865) Hereditary talent and character. Macmillans Magazine 12: 157Google Scholar
  16. 16.
    Garrod AE (1902) The incidence of alcaptonuria: a study in chemical individuality. Lancet 2: 1616–1620CrossRefGoogle Scholar
  17. 17.
    Garrod AE (1923) Inborn errors of metabolism. Frowde, London (reprinted by Oxford University Press, London 1963 )Google Scholar
  18. 18.
    Graham LR (1977) Political ideology and genetic theory: Russia and Germany in the 1920’s. Hastings Cent Rep 7: 30–39PubMedGoogle Scholar
  19. 19.
    Hardy GH (1908) Mendelian proportions in a mixed population. Science 28: 49–50PubMedCrossRefGoogle Scholar
  20. 20.
    Harris H (1969) Enzyme and protein polymorphism in human populations. Br Med Bull 25: 5PubMedGoogle Scholar
  21. 21.
    Harris H, Watkins JF (1965) Hybrid cells from mouse and man: artificial heterokyryons of mammalian cells from different species. Nature 205: 640PubMedCrossRefGoogle Scholar
  22. 22.
    Joraysky D (1970) The Lysenko affair. Harvard University Press, BostonGoogle Scholar
  23. 23.
    Kevles DJ (1985) In the name of eugenics. Genetics and the uses of human heredity. Knopf, New YorkGoogle Scholar
  24. 24.
    Kühl S (1994) The Nazi connection. Eugenics, American racism, and German national socialism. Oxford University Press, OxfordGoogle Scholar
  25. 25.
    Landsteiner K (1900) Zur Kenntnis der antifermentativen, lytischen und agglutinierenden Wirkungen des Blutserums und der Lymphe. Zentralbl Bakteriol 27: 357–362Google Scholar
  26. 26.
    Landsteiner K, Wiener AS (1940) An agglutinable factor in human blood recognized by immune sera for rhesus blood. Proc Soc Exp Biol 43: 223Google Scholar
  27. 27.
    Levine P, Stetson RE (1939) An unusual case of intragroup agglutination. JAMA 113: 126–127CrossRefGoogle Scholar
  28. 28.
    Levine P, Burnham L, Katzin EM, Vogel P (1941) The role of isoimmunization in the pathogenesis of erythroblastosis fetalis. Am J Obstet Gynecol 42: 925–937Google Scholar
  29. 29.
    Ludmerer K (1972) Genetics and American society. Johns Hopkins University Press, BaltimoreGoogle Scholar
  30. 30.
    McKusick VA (1975) The growth and development of human genetics as a clinical discipline. Am J Hum Genet 27: 261–273PubMedGoogle Scholar
  31. 31.
    Mendel GJ (1865) Versuche über Pflanzenhybriden. Verhandlungen des Naturforschenden Vereins, BrünnGoogle Scholar
  32. 32.
    Motulsky AG (1959) Joseph Adams (1756–1818). Arch Intern Med 104: 490–496PubMedCrossRefGoogle Scholar
  33. 33.
    Motulsky AG (1972) History and current status of pharmacogenetics. In: Human Genetics. Proceedings of the 4th International Congress of Human Genetics. Paris, September 1971. Excerpta Medica, Amsterdam, pp 381–390Google Scholar
  34. 34.
    Motulsky AG (1977) Ecogenetics: genetic variation in susceptibility to environmental agents. In: Human Genetics. Proceedings of the 5th International Congress of Human Genetics. Mexico City, 10–15 October 1976. Excerpta Medica, Amsterdam, pp 375–385Google Scholar
  35. 35.
    Motulsky AG (1978) The genetics of common diseases. In: Morton NE, Chung CS (eds) Genetic epidemiology. Academic, New York, pp 541–548Google Scholar
  36. 36.
    Motulsky AG (1978) Presidential address: Medical and human genetics 1977: trends and directions. Am J Hum Genet 30: 123–131PubMedGoogle Scholar
  37. 37.
    Motulsky AG (1984) Genetic epidemiology. Genet Epidemiol 1: 143–144PubMedCrossRefGoogle Scholar
  38. 38.
    Müller-Hill B (1984) Tödliche Wissenschaft. Rowohlt, HamburgGoogle Scholar
  39. 39.
    Nachtsheim H (1952) Für und wider die Sterilisierung aus eugenischer Indikation. Thieme, StuttgartGoogle Scholar
  40. 40.
    Pauling L, Itano HA, Singer SJ, Wells IC (1949) Sickle cell anemia: a molecular disease. Science 10: 543CrossRefGoogle Scholar
  41. 41.
    Penrose LS (1967) Presidential address–the influence of the English tradition in human genetics. In: Crow JF, Neel JV (eds) Proceedings of the 3rd International Congress of Human Genetics. Johns Hopkins University Press, Baltimore, pp 13–25Google Scholar
  42. 42.
    Ploetz A (1895) Die Tüchtigkeit unserer Rasse und der Schutz der Schwachen: ein Versuch über Rassenhygiene und ihr Verhältnis zu den humanen Idealen, besonders zum Sozialismus. Fischer, BerlinGoogle Scholar
  43. 43.
    Pollack W, Gorman JG, Freda VJ (1969) Prevention of Rh hemolytic disease. Prog Hematol 6: 121–147PubMedGoogle Scholar
  44. 44.
    Reitlinger G (1961) The final solution. Barnes, New YorkGoogle Scholar
  45. 45.
    Rosenberg CE (1976) No other gods. On science and American social thought. Johns Hopkins University Press, BaltimoreGoogle Scholar
  46. 46.
    Scriver CR, Childs B (1989) Garrod’s inborn factors in disease. Oxford University Press, OxfordGoogle Scholar
  47. 47.
    Von Dungern E, Hirszfeld L (1911) On the group-specific structures of the blood. III. Z Immunitatsforsch 8: 526–562Google Scholar
  48. 48.
    Von Verschuer O (1937) Was kann der Historiker, der Genealoge und der Statistiker zur Erforschung des biologischen Problems der Judenfrage beitragen? Forschungen zur Judenfrage 2: 216–222Google Scholar
  49. 49.
    Weatherall DJ (1985) The new genetics and clinical practice. Oxford University Press, OxfordGoogle Scholar
  50. 50.
    Weiling F (1994) Johann Gregor Mendel. Forscher in der Kontroverse. V. Med Genet 6: 35–50Google Scholar
  51. 51.
    Weinberg W (1901) Beiträge zur Physiologie und Pathologie der Mehrlingsgeburten beim Menschen. Arch Gesamte Physiol 88: 346–430CrossRefGoogle Scholar
  52. 52.
    Weinberg W (1908) Über den Nachweis der Vererbung beim Menschen. Jahreshefte des Vereins für vaterländische Naturkunde in Württemberg 64: 368–382Google Scholar
  53. 53.
    Weinberg W (1912) Weitere Beiträge zur Theorie der Vererbung. IV. Über Methode und Fehlerquellen der Untersuchung auf Mendelsche Zahlen beim Menschen. Arch Rass Ges Biol 9: 165–174Google Scholar
  54. 54.
    Weindling PF (1989) Health, race and German politics between national unification and nazism 1870–1945. Cambridge University Press, CambridgeGoogle Scholar
  55. 55.
    Weingart P, Kroll J, Bayertz K (1988) Rasse, Blut und Gene. Suhrkamp, FrankfurtGoogle Scholar
  56. 56.
    Zimmerman D (1973) Rh. The intimate history of a disease and its conquest. Macmillan, New York, p 371Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Friedrich Vogel
    • 1
  • Arno G. Motulsky
    • 2
  1. 1.Institut für Humangenetik und AnthropologieHeidelbergGermany
  2. 2.Division of Medical Genetics, School of MedicineUniversity of WashingtonSeattleUSA

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