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Anti-arthrotic and immunmodulatory activity

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Drug Discovery and Evaluation

Abstract

Multifactorial causes can lead to osteoarthritis (OA), and its pathogenesis is not clearly understood as yet. The main characteristics of OA are the slowly progressing deterioration of the articular cartilage, accompanied by intermitted painful inflammatory episodes, and a continuous subchondral bone remodeling, often resulting in osteophyte formation in nonweight-bearing joint areas. Because of the lack of innervation and vascularization of cartilage, the destruction of this specific tissue remains unnoticed until other joint compartments are involved such as synovial membranes, answering with reactive synovitis to cartilage debris, or mechanoreception changes in the underlying bone, or until the diminution of articular cartilage results in a radiographically detectable joint space narrowing.

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  1. Johann Wolfgang Goethe Universität Frankfurt, D-60569, Frankfurt am Main, Germany

    Prof. Dr. med. Dr.s.c. H. Gerhard Vogel

  2. Philipps Universität Marburg, D-35037, Marburg, Germany

    Prof. Dr. med. Dr.s.c. H. Gerhard Vogel

  3. Department of Pharmacology Jefferson Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    Professor Dr. Wolfgang H. Vogel

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  1. Johann Wolfgang Goethe Universität Frankfurt, D-60569, Frankfurt am Main, Germany

    H. Gerhard Vogel

  2. Philipps Universität Marburg, D-35037, Marburg, Germany

    H. Gerhard Vogel

  3. Department of Pharmacology Jefferson Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    Wolfgang H. Vogel

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Vogel, H.G., Vogel, W.H. (1997). Anti-arthrotic and immunmodulatory activity. In: Vogel, H.G., Vogel, W.H. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03333-3_9

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