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Respiratory activity

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Drug Discovery and Evaluation

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Abstract

Histamine is considered to play a major role in asthmatic attacks. H1-antagonists have been used since decades as therapeutic agents. This assay is used to determine the affinity of test compounds to the histamine H1 receptor by measuring their inhibitory activities on the binding of the H1 antagonist 3H-pyrilamine to a plasma membrane preparation from guinea pig brain.

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  1. Johann Wolfgang Goethe Universität Frankfurt, D-60569, Frankfurt am Main, Germany

    Prof. Dr. med. Dr.s.c. H. Gerhard Vogel

  2. Philipps Universität Marburg, D-35037, Marburg, Germany

    Prof. Dr. med. Dr.s.c. H. Gerhard Vogel

  3. Department of Pharmacology Jefferson Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    Professor Dr. Wolfgang H. Vogel

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    H. Gerhard Vogel

  2. Philipps Universität Marburg, D-35037, Marburg, Germany

    H. Gerhard Vogel

  3. Department of Pharmacology Jefferson Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    Wolfgang H. Vogel

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Vogel, H.G., Vogel, W.H. (1997). Respiratory activity. In: Vogel, H.G., Vogel, W.H. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03333-3_4

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