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Activity on the gastrointestinal tract

  • Chapter
Drug Discovery and Evaluation

Abstract

Symptoms of several human diseases are manifested as increased salivation (e.g., Parkinson’s disease) or decreased salivation (e.g., xerosis). Studies to find and to evaluate sialagogues, such as substance P and its synthetic derivatives, as well as to search for salivation inhibitors are necessary. Saliva excretion is greatly influenced by anesthetics. Wagner et al (1991) proposed a simple method to study saliva secretion in conscious rats and to evaluate sialagogues and sialagogue antagonists.

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Authors and Affiliations

  1. Johann Wolfgang Goethe Universität Frankfurt, D-60569, Frankfurt am Main, Germany

    Prof. Dr. med. Dr.s.c. H. Gerhard Vogel

  2. Philipps Universität Marburg, D-35037, Marburg, Germany

    Prof. Dr. med. Dr.s.c. H. Gerhard Vogel

  3. Department of Pharmacology Jefferson Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    Professor Dr. Wolfgang H. Vogel

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  1. Johann Wolfgang Goethe Universität Frankfurt, D-60569, Frankfurt am Main, Germany

    H. Gerhard Vogel

  2. Philipps Universität Marburg, D-35037, Marburg, Germany

    H. Gerhard Vogel

  3. Department of Pharmacology Jefferson Medical College, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    Wolfgang H. Vogel

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Vogel, H.G., Vogel, W.H. (1997). Activity on the gastrointestinal tract. In: Vogel, H.G., Vogel, W.H. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03333-3_10

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