Inflammation in the CNS and in Alzheimer’s Disease

  • V. H. Perry
  • M. D. Bell
  • D. Anthony
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 17)

Abstract

The cellular response to neuronal injury or neuronal degeneration in the central nervous system (CNS) is commonly referred to as gliosis. Tradi-tionally, this term was used to refer to the response by astroglia but in more recent years has come to refer to the whole spectrum of cellular reactions to neuronal damage. Since the glia, astroglia, oligodendroglia and microglia are the non-neuronal constituents of the CNS, the term gliosis suggests that this response is wholly intrinsic to the CNS com-partment without a contribution from blood-derived leucocytes. In other tissues cellular degeneration is accompanied by an acute innate inflam-matory response and leucocyte recruitment from the blood but in the CNS the term inflammation appears to have been widely used only in conditions where there is also an overt leucocyte infiltrate such as that seen in multiple sclerosis or viral infections of the CNS. Is it really the case that there is no inflammatory response when neurones degenerate? Is neuronal degeneration accompanied by a more subtle form of inflammation than that seen in other tissues?

Keywords

Dementia Dexamethasone Glucocorticoid Neurol Integrin 

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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • V. H. Perry
  • M. D. Bell
  • D. Anthony

There are no affiliations available

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