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Therapeutic Significance of Apoptosis in the Treatment of Androgen-Dependent and Androgen-Independent Prostate Cancer

  • Conference paper
Apoptosis in Hormone-Dependent Cancers

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 14))

  • 44 Accesses

Abstract

Prostate cancer is the most commonly diagnosed malignancy in men in the United States and a major contributor to cancer mortality. The disease has a remarkably high annual mortality rate, with 38 000 men dying each year from metastatic prostate cancer (Boring et al. 1993). Due to the rapid rise in aging of the US population, it is estimated that by the year 2000 there will be a 37% increase in prostate cancer deaths (Carter and Coffey 1990). Approximately 200 000 new cases of prostate cancer are clinically diagnosed each year. The disease varies widely in its clinical aggressiveness. In some patients, prostate cancer metastasizes rapidly, killing the patient within a year of initial clinical presentation, whereas other patients may live for many years with localized disease without apparent metastases. At the same time, prostate cancer is often characterized as being clinically “silent” in a large number of men who harbor it histologically. An inviting challenge in prostate cancer research, therefore, is to distinguish prostatic tumors destined to progress to lethal metastatic disease from those with little likelihood of causing morbidity.

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Authors
  1. N. Kyprianou
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Editors and Affiliations

  1. W. Alton Jones Cell Science Center, 10 Old Barn Road, 12946, Lake Placid, NY, USA

    Martin Tenniswood

  2. Research Laboratories, Schering AG, Müllerstraße 170-178, 13342, Berlin, Germany

    Horst Michna

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© 1995 Springer-Verlag Berlin Heidelberg

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Kyprianou, N. (1995). Therapeutic Significance of Apoptosis in the Treatment of Androgen-Dependent and Androgen-Independent Prostate Cancer. In: Tenniswood, M., Michna, H. (eds) Apoptosis in Hormone-Dependent Cancers. Ernst Schering Research Foundation Workshop, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03122-3_3

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  • DOI: https://doi.org/10.1007/978-3-662-03122-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03124-7

  • Online ISBN: 978-3-662-03122-3

  • eBook Packages: Springer Book Archive

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