Infantile-Onset Leukoencephalopathy with Swelling and a Discrepantly Mild Clinical Course

  • Marjo S. van der Knaap
  • Jacob Valk


Recently, an as yet unidentified disease, characterized by cerebral leukoencephalopathy and megalencephaly with infantile onset, was discovered (Van der Knaap et al. 1993, 1994a,b,c, 1995a,b). Considering the high rate of consanguinity among the parents and the presence of two affected sibs in one family, an autosomal recessive mode of inheritance can be assumed.


White Matter Muscular Dystrophy Internal Capsule Alexander Disease Infantile Onset 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Marjo S. van der Knaap
    • 1
  • Jacob Valk
    • 2
  1. 1.Department of Child NeurologyFree University HospitalAmsterdamThe Netherlands
  2. 2.Department of Diagnostic RadiologyFree University HospitalAmsterdamThe Netherlands

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