Differentiation of Human Monocytes In Vitro: A Model of Macrophage Ontogeny

  • R. Andreesen
  • M. Kreutz
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 11)

Abstract

Monocytes are the common “precursor” of the different types of macrophages which are distributed ubiquitous in all tissues. Monocytes and granulocytes both originate from committed progenitor cells in the bone marrow (colony-forming unit granulocyte-macrophage, CFU-GM). Glycoprotein hormones termed colony-stimulating factors [CSF; macrophage CSF (M-CSF), granulocyte-macrophage CSF (GM-CSF)] or interleukin-3 (IL-3; multi-CSF) regulate the differentiation of this stem cell into monoblasts which then differentiate into promonocytes (Metcalf 1991).

Keywords

Migration Toxicity Albumin Leukemia Interferon 

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© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • R. Andreesen
  • M. Kreutz

There are no affiliations available

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