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Differentiation of Human Monocytes In Vitro: A Model of Macrophage Ontogeny

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Cell Culture in Pharmaceutical Research

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 11))

Abstract

Monocytes are the common “precursor” of the different types of macrophages which are distributed ubiquitous in all tissues. Monocytes and granulocytes both originate from committed progenitor cells in the bone marrow (colony-forming unit granulocyte-macrophage, CFU-GM). Glycoprotein hormones termed colony-stimulating factors [CSF; macrophage CSF (M-CSF), granulocyte-macrophage CSF (GM-CSF)] or interleukin-3 (IL-3; multi-CSF) regulate the differentiation of this stem cell into monoblasts which then differentiate into promonocytes (Metcalf 1991).

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Authors
  1. R. Andreesen
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  2. M. Kreutz
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Editors and Affiliations

  1. Division of Differentiation and Carcinogenesis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    N. E. Fusenig

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Andreesen, R., Kreutz, M. (1994). Differentiation of Human Monocytes In Vitro: A Model of Macrophage Ontogeny. In: Fusenig, N.E., Graf, H. (eds) Cell Culture in Pharmaceutical Research. Ernst Schering Research Foundation Workshop, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03011-0_2

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  • DOI: https://doi.org/10.1007/978-3-662-03011-0_2

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