Low Molecular Weight GTP-binding Proteins in Rough Endoplasmic Reticulum Membranes from Rat Liver and Rat Hepatocellular Carcinomas
Physiological concentrations of GTP have been shown to stimulate a variety of biochemical and morphological events in rough endoplasmic reticulum (RER) membranes. This includes Ca+ + release, protein translocation, core glycosylation, membrane permeability changes, phospholipid metabolism and membrane fusion. In effort to identify GTP-binding proteins involved in specific RER functions we have looked for similar proteins in a rat liver membrane preparation enriched in derivatives of RER. Furthermore, we have studied the effects of a variety of post-translational modifications of GTP-binding proteins on GTP-dependent membrane fusion.
KeywordsPermeability Urea Electrophoresis Sorting Guanine
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