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A Short N-Terminal Sequence is Responsible for the Retention of Invariant Chain (Ii) in the Endoplasmic Reticulum

  • Marie-Paule Schutze
  • Michael R. Jackson
  • Per A. Peterson
Conference paper
Part of the NATO ASI Series book series (volume 74)

Abstract

Proteins destined for the exocytic pathway are directed into the endoplasmic reticulum (ER) by an N-terminal signal peptide. Current views support the idea that transport occurs by default such that proteins inserted into the ER are carried passively to the cell surface unless retained by structural motifs (Pfeffer and Rothman 1987). In the case of ER resident proteins, such motifs have been identified for both lumenal and type I transmembrane proteins (Munro and Pelham 1987, Jackson et al 1990). When transplanted onto reporter proteins, these motifs maintain the chimeric proteins in the ER.

Keywords

Endoplasmic Reticulum Transmembrane Protein Chimeric Protein Reporter Protein Invariant Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Marie-Paule Schutze
    • 1
  • Michael R. Jackson
    • 1
  • Per A. Peterson
    • 1
  1. 1.Dept. ImmunologyThe Scripps Research InstituteLa JollaUSA

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