A Short N-Terminal Sequence is Responsible for the Retention of Invariant Chain (Ii) in the Endoplasmic Reticulum
Proteins destined for the exocytic pathway are directed into the endoplasmic reticulum (ER) by an N-terminal signal peptide. Current views support the idea that transport occurs by default such that proteins inserted into the ER are carried passively to the cell surface unless retained by structural motifs (Pfeffer and Rothman 1987). In the case of ER resident proteins, such motifs have been identified for both lumenal and type I transmembrane proteins (Munro and Pelham 1987, Jackson et al 1990). When transplanted onto reporter proteins, these motifs maintain the chimeric proteins in the ER.
KeywordsEndoplasmic Reticulum Transmembrane Protein Chimeric Protein Reporter Protein Invariant Chain
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