Protein Trafficking along the Exocytotic Pathway
The exocytotic (secretory) pathway is composed of the endoplasmic reticulum (ER), the Golgi apparatus, the endosomal/lysosomal/lysosomal system, the plasma membrane, which is separated into apical and basolateral domains in epithelial cells, and various vesicular and tubular intermediates that connect dynamically these membrane compartments. The signals and molecular mechanisms that govern the selective targeting of proteins to various compartments of the exocytotic pathway are the major focus of the laboratory.
KeywordsDipeptidyl Peptidase Mock Cell Apical Cell Surface Basolateral Domain Surface Membrane Protein
- Low SH, Tang BL, Wong SH, Hong W (1992) Selective inhibition of protein targeting to the apical domain of MDCK cells by brefeldin A. J Cell Biol, in pressGoogle Scholar