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Protein Trafficking along the Exocytotic Pathway

  • Wanjin Hong
Conference paper
Part of the NATO ASI Series book series (volume 74)

Abstract

The exocytotic (secretory) pathway is composed of the endoplasmic reticulum (ER), the Golgi apparatus, the endosomal/lysosomal/lysosomal system, the plasma membrane, which is separated into apical and basolateral domains in epithelial cells, and various vesicular and tubular intermediates that connect dynamically these membrane compartments. The signals and molecular mechanisms that govern the selective targeting of proteins to various compartments of the exocytotic pathway are the major focus of the laboratory.

Keywords

Dipeptidyl Peptidase Mock Cell Apical Cell Surface Basolateral Domain Surface Membrane Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Low SH, Wong SH, Tang BL, Subramaniam VN, Hong W (1991a) Apical cell surface expression of rat dipeptidyl peptidase IV in transfected MDCK cells. J Biol Chem 266: 13391–13396PubMedGoogle Scholar
  2. Low SH, Wong SH, Tang, BL, Tan P, Subramaniam VN, Hong W (1991b) Inhibition by brefeldin A of protein secretion from the apical cell surface of Madin-Darby canine kidney cells. J Biol Chem 266: 17729–17732PubMedGoogle Scholar
  3. Low SH, Tang BL, Wong SH, Hong W (1992) Selective inhibition of protein targeting to the apical domain of MDCK cells by brefeldin A. J Cell Biol, in pressGoogle Scholar
  4. Tang BL, Wong SH, Low SH, Hong W (1992a) Retention of a type II surface membrane protein in the endoplasmic reticulum by the Lys-Asp-Glu-Leu sequence. J Biol Chem 267: 7072–7076PubMedGoogle Scholar
  5. Tang BL, Wong SH, Low SH, Hong W (1992b) The transmembrane domain of Nacetylglucosaminyltransferase I contains a Golgi retention signal. J Biol Chem 267: 10122–10126PubMedGoogle Scholar
  6. Wong SH, Low SH, Hong W (1992) The 17-residue transmembrane domain of pgalactoside e2,6-sialytransferase is sufficient for Golgi retention. J Cell Biol 117: 245–258PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Wanjin Hong
    • 1
  1. 1.Institute of Molecular and Cell BiologyNational University of SingaporeSingapore 0511Singapore

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